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Atrial Fibrillation > What Your Doctor is Reading About Atrial Fibrillation > Clinical Trials

Clinical Trials

1. Pulmonary vein isolation combined with superior vena cava isolation for atrial fibrillation ablation: a prospective randomized study.

Author: Wang XH; Liu X; Sun YM; Shi HF; Zhou L; Gu JN;
Institution: Department of Cardiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, People's Republic of China.
Journal: Europace. 2008 May;10(5):600-5.
Abstract URL: Click here to view abstract

2. Optimal heart failure therapy and successful cardioversion in heart failure patients with atrial fibrillation.

Author: Boldt LH; Rolf S; Huemer M; Parwani AS; Luft FC; Dietz R; Haverkamp W; Boldt LH; Rolf S; Huemer M; Parwani AS; Luft FC; Dietz R; Haverkamp W;
Institution: Department of Cardiology, Charite-Campus Virchow Clinic, Berlin, Germany. leif-hendrik.boldt@charite.de
Journal: Am Heart J. 2008 May;155(5):890-5. Epub 2008 Feb 15.
Abstract URL: Click here to view abstract

3. Efficacy and safety of the additional bepridil treatment in patients with atrial fibrillation refractory to class I antiarrhythmic drugs.

Author: Miyaji K; Tada H; Fukushima Kusano K; Hashimoto T; Kaseno K; Hiramatsu S; Tadokoro K; Naito S; Nakamura K; Oshima S; Taniguchi K; Ohe T;
Institution: Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, and Department of Cardiovascular Medicine, Okayama University Graduated School of Medicine, Density and Pharmaceutical Science, Japan.
Journal: Circ J. 2007 Aug;71(8):1250-7.
Abstract URL: Click here to view abstract

4. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial.

Author: Mant J; Hobbs FD; Fletcher K; Roalfe A; Fitzmaurice D; Lip GY; Murray E;
Institution: Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK. j.w.mant@bham.ac.uk
Journal: Lancet. 2007 Aug 11;370(9586):493-503.
Abstract URL: Click here to view abstract

5. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.

Author: Singh BN; Connolly SJ; Crijns HJ; Roy D; Kowey PR; Capucci A; Radzik D; Aliot EM; Hohnloser SH;
Institution: Cardiology Division, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA. bsingh@ucla.edu
Journal: N Engl J Med. 2007 Sep 6;357(10):987-99.
Abstract URL: Click here to view abstract

6. Rhythm control versus rate control for atrial fibrillation and heart failure.

Author: Roy D; Talajic M; Nattel S; Wyse DG; Dorian P; Lee KL; Bourassa MG; Arnold JM; Buxton AE; Camm AJ; Connolly SJ; Dubuc M; Ducharme A; Guerra PG; Hohnloser SH; Lambert J; Le Heuzey JY; O'Hara G; Pedersen OD; Rouleau JL; Singh BN; Stevenson LW; Stevenson WG; Thibault B; Waldo AL;
Institution: Montreal Heart Institute and the Universite de Montreal, Montreal, QC H1T 1C8, Canada. d_roy@icm-mhi.com
Journal: N Engl J Med. 2008 Jun 19;358(25):2667-77.
Abstract URL: Click here to view abstract

7. Dose-response effect of flecainide in patients with symptomatic paroxysmal atrial fibrillation and/or flutter monitored with trans-telephonic electrocardiography: a multicenter, placebo-controlled, double-blind trial.

Author: Atarashi H; Ogawa S; Inoue H; Hamada C;
Institution: Department of Internal Medicine, Nippon Medical School, Tama-Nagayama Hospital, Japan. atarashi@nms.ac.jp
Journal: Circ J. 2007 Mar;71(3):294-300.
Abstract URL: Click here to view abstract

8. Stepwise linear approach to catheter ablation of atrial fibrillation.

Author: Yao Y; Zheng L; Zhang S; He DS; Zhang K; Tang M; Chen K; Pu J; Wang F; Chen X;
Institution: Clinical EP Laboratory and Arrhythmia Service Center of Fuwai Heart Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. ianyao@263.net.cn
Journal: Heart Rhythm. 2007 Dec;4(12):1497-504. Epub 2007 Aug 11.
Abstract URL: Click here to view abstract

9. Effect of ximelagatran on ischemic events and death in patients with atrial fibrillation after acute myocardial infarction in the efficacy and safety of the oral direct thrombin inhibitor ximelagatran in patients with recent myocardial damage (ESTEEM) trial.

Author: Tangelder MJ; Frison L; Weaver D; Wilcox RG; Bylock A; Emanuelsson H; Held P; Oldgren J;
Institution: AstraZeneca R&D, Medical Science, Molndal, Sweden. marco.tangelder@astrazeneca.com
Journal: Am Heart J. 2008 Feb;155(2):382-7.
Abstract URL: Click here to view abstract

10. Effect of dexamethasone on atrial fibrillation after cardiac surgery: prospective, randomized, double-blind, placebo-controlled trial.

Author: Yared JP; Bakri MH; Erzurum SC; Moravec CS; Laskowski DM; Van Wagoner DR; Mascha E; Thornton J;
Institution: Department of Cardiothoracic Anesthesiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. yaredj@ccf.org
Journal: J Cardiothorac Vasc Anesth. 2007 Feb;21(1):68-75. Epub 2006 Feb 14.
Abstract URL: Click here to view abstract

11. Plasma natriuretic peptide concentrations as a predictor for successful catheter ablation in patients with drug-refractory atrial fibrillation.

Author: Kurosaki K; Tada H; Hashimoto T; Ito S; Miyaji K; Naito S; Oshima S; Taniguchi K;
Institution: Department of Cardiology, Jichi Medical School, Minamikawachi, Japan.
Journal: Circ J. 2007 Mar;71(3):313-20.
Abstract URL: Click here to view abstract

12. Exercise capacity in atrial fibrillation: a substudy of the Sotalol-Amiodarone Atrial Fibrillation Efficacy Trial (SAFE-T).

Author: Atwood JE; Myers JN; Tang XC; Reda DJ; Singh SN; Singh BN;
Institution: Cardiology Division, Walter Reed Army Medical Center, 6900 Georgia Ave NW, Washington, DC 20307, USA. john.atwood@amedd.army.mil
Journal: Am Heart J. 2007 Apr;153(4):566-72.
Abstract URL: Click here to view abstract

13. Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy.

Author: Hohnloser SH; Pajitnev D; Pogue J; Healey JS; Pfeffer MA; Yusuf S; Connolly SJ;
Institution: Department of Cardiology, Division of Electrophysiology, J. W. Goethe University, Frankfurt, Germany. Hohnloser@em.uni-frankfurt.de
Journal: J Am Coll Cardiol. 2007 Nov 27;50(22):2156-61. Epub 2007 Nov 13.
Abstract URL: Click here to view abstract

14. Atrial fibrillation ablation in patients with therapeutic international normalized ratio: comparison of strategies of anticoagulation management in the periprocedural period.

Author: Wazni OM; Beheiry S; Fahmy T; Barrett C; Hao S; Patel D; Di Biase L; Martin DO; Kanj M; Arruda M; Cummings J; Schweikert R; Saliba W; Natale A;
Institution: Center for Atrial Fibrillation, Cleveland Clinic, 60 Stonewood Dr, Cleveland, OH 44022, USA.
Journal: Circulation. 2007 Nov 27;116(22):2531-4. Epub 2007 Nov 12.
Abstract URL: Click here to view abstract

15. Radiofrequency ablation of atypical atrial flutter after cardiac surgery or atrial fibrillation ablation: a randomized comparison of open-irrigation-tip and 8-mm-tip catheters.

Author: Bai R; Fahmy TS; Patel D; Di Biase L; Riedlbauchova L; Wazni OM; Schweikert RA; Burkhardt JD; Saliba W; Natale A;
Institution: Department of Cardiovascular Medicine, Section of Cardiac Electrophysiology and Pacing, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Journal: Heart Rhythm. 2007 Dec;4(12):1489-96. Epub 2007 Aug 1.
Abstract URL: Click here to view abstract

16. A randomized comparison of amiodarone and class IC antiarrhythmic drugs to treat atrial fibrillation in patients paced for sinus node disease: the Prevention Investigation and Treatment: A Group for Observation and Research on Atrial arrhythmias (PITAGORA) trial.

Author: Gulizia M; Mangiameli S; Orazi S; Chiaranda G; Piccione G; Di Giovanni N; Colletti A; Pensabene O; Lisi F; Vasquez L; Grammatico A; Boriani G;
Institution: Garibaldi-Nesima Hospital, Catania, Italy. michele.gulizia@tin.it
Journal: Am Heart J. 2008 Jan;155(1):100-7, 107.e1. Epub 2007 Nov 26.
Abstract URL: Click here to view abstract

17. Radiofrequency ablation of atrial fibrillation: is the persistence of all intraprocedural targets necessary for long-term maintenance of sinus rhythm?

Author: Pratola C; Baldo E; Notarstefano P; Toselli T; Ferrari R;
Institution: St Anna University Hospital, Corso Giovecca 203, 44100 Ferrara, Italy.
Journal: Circulation. 2008 Jan 15;117(2):136-43. Epub 2007 Dec 17.
Abstract URL: Click here to view abstract

18. Effect of statin dose on incidence of atrial fibrillation: data from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) and Aggrastat to Zocor (A to Z) trials.

Author: McLean DS; Ravid S; Blazing M; Gersh B; Shui A; Cannon CP;
Institution: Cardiovascular Division, Department of Medicine, Thrombolysis in Myocardial Infarction Study Group, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Journal: Am Heart J. 2008 Feb;155(2):298-302.
Abstract URL: Click here to view abstract

19. Post-cardioversion transesophageal echocardiography (POSTEC) strategy with the use of enoxaparin for brief anticoagulation in atrial fibrillation patients: the multicenter POSTEC trial (a pilot study).

Author: Sorino M; Colonna P; De Luca L; Carerj S; Oliva E; De Tommasi SM; Conti U; Iacopi F; D'Agostino C; D'Amato N; Pettinati G; Montericcio V; Cualbu A; De Luca I;
Institution: Division of Cardiology, Policlinico Hospital of Bari, Bari, Italy.
Journal: J Cardiovasc Med (Hagerstown). 2007 Dec;8(12):1034-42.
Abstract URL: Click here to view abstract

20. Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W).

Author: Healey JS; Hart RG; Pogue J; Pfeffer MA; Hohnloser SH; De Caterina R; Flaker G; Yusuf S; Connolly SJ;
Institution: Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada. healeyj@hhsc.ca
Journal: Stroke. 2008 May;39(5):1482-6. Epub 2008 Mar 6.
Abstract URL: Click here to view abstract

21. Atrial fibrillation correction surgery: lessons from the Society of Thoracic Surgeons National Cardiac Database.

Author: Gammie JS; Haddad M; Milford-Beland S; Welke KF; Ferguson TB Jr; O'Brien SM; Griffith BP; Peterson ED;
Institution: Division of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA. jgammie@smail.umaryland.edu
Journal: Ann Thorac Surg. 2008 Mar;85(3):909-14.
Abstract URL: Click here to view abstract

22. Functional capacity after traditional Chinese medicine (qi gong) training in patients with chronic atrial fibrillation: a randomized controlled trial.

Author: Pippa L; Manzoli L; Corti I; Congedo G; Romanazzi L; Parruti G;
Institution: Camillo de Lellis per la Ricera Clinica Applicata, Pescara, Italy.
Journal: Prev Cardiol. 2007 Winter;10(1):22-5.
Abstract URL: Click here to view abstract

23. Descriptive analysis of the process and quality of oral anticoagulation management in real-life practice in patients with chronic non-valvular atrial fibrillation: the international study of anticoagulation management (ISAM).

Author: Ansell J; Hollowell J; Pengo V; Martinez-Brotons F; Caro J; Drouet L;
Institution: Department of Medicine, E113, Boston University Medical Center, 88 E. Newton St., Boston, MA, 02118, USA. jack.ansell@bmc.org
Journal: J Thromb Thrombolysis. 2007 Apr;23(2):83-91.
Abstract URL: Click here to view abstract

24. Digitalis: a dangerous drug in atrial fibrillation? An analysis of the SPORTIF III and V data.

Author: Gjesdal K; Feyzi J; Olsson SB; Gjesdal K; Feyzi J; Olsson SB;
Institution: Ulleval University Hospital, 0407 Oslo, Norway. knut.gjesdal@medisin.uio.no
Journal: Heart. 2008 Feb;94(2):191-6. Epub 2007 May 4.
Abstract URL: Click here to view abstract