Saturday, September 6, 2008 - 2:23PM EST

Clinical Trials

1. Phase II evaluation of an intensified induction therapy with standard daunomycin and cytarabine followed by high dose cytarabine for adults with previously untreated acute myeloid leukemia: a Southwest Oncology Group study (SWOG-9500).

Author
Petersdorf SH; Rankin C; Head DR; Terebelo HR; Willman CL; Balcerzak SP; Karnad AB; Dakhil SR; Appelbaum FR;
Institution
Division of Medical Oncology, Seattle Cancer Care Alliance, Fred Hutchinson Cancer Research Center, Puget Sound Oncology Consortium, Seattle, Washington 98109, USA. spetersd@u.washington.edu
Journal
Am J Hematol. 2007 Dec;82(12):1056-62.
Abstract URL
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2. A double-blind trial on prophylactic voriconazole (VRC) or placebo during induction chemotherapy for acute myelogenous leukaemia (AML).

Author
Vehreschild JJ; Bohme A; Buchheidt D; Arenz D; Harnischmacher U; Heussel CP; Ullmann AJ; Mousset S; Hummel M; Frommolt P; Wassmer G; Drzisga I; Cornely OA;
Institution
Klinikum der Universitat zu Koln, Klinik I fur Innere Medizin, Studienzentrum Infektiologie II, 50937 Koln, Germany.
Journal
J Infect. 2007 Nov;55(5):445-9. Epub 2007 Sep 6.
Abstract URL
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3. Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation.

Author
Pollyea DA; Artz AS; Stock W; Daugherty C; Godley L; Odenike OM; Rich E; Smith SM; Zimmerman T; Zhang Y; Huo D; Larson R; van Besien K;
Institution
Department of Internal Medicine, University of Chicago Hospitals, Chicago, IL 60637, USA.
Journal
Bone Marrow Transplant. 2007 Dec;40(11):1027-32. Epub 2007 Sep 10.
Abstract URL
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4. Hematopoietic cell transplantation specific comorbidity index as an outcome predictor for patients with acute myeloid leukemia in first remission: combined FHCRC and MDACC experiences.

Author
Sorror ML; Giralt S; Sandmaier BM; De Lima M; Shahjahan M; Maloney DG; Deeg HJ; Appelbaum FR; Storer B; Storb R;
Institution
Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA 98109-1024, USA. msorror@fhcrc.org
Journal
Blood. 2007 Dec 15;110(13):4606-13. Epub 2007 Sep 14.
Abstract URL
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5. Gemtuzumab ozogamicin, cytosine arabinoside, G-CSF combination (G-AraMy) in the treatment of elderly patients with poor-prognosis acute myeloid leukemia.

Author
Fianchi L; Pagano L; Leoni F; Storti S; Voso MT; Valentini CG; Rutella S; Scardocci A; Caira M; Gianfaldoni G; Leone G;
Institution
Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Roma, Italy. luana.fianchi@rm.unicatt.it
Journal
Ann Oncol. 2008 Jan;19(1):128-34. Epub 2007 Sep 28.
Abstract URL
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6. Gemtuzumab ozogamicin in combination with attenuated doses of standard induction chemotherapy can successfully induce complete remission without increasing toxicity in patients with acute myeloid leukemia aged 55 or older.

Author
Eom KS; Kim HJ; Min WS; Lee S; Min CK; Cho BS; Kim SY; Kim YJ; Lee DG; Choi SM; Cho SG; Kim DW; Lee JW; Shin WS; Kim CC;
Institution
Catholic Hematopoietic Stem Cell Transplantation Center, St Mary's Hospital, The Catholic University of Korea, Seoul, Korea. dreom@catholic.ac.kr
Journal
Eur J Haematol. 2007 Nov;79(5):398-404. Epub 2007 Oct 4.
Abstract URL
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7. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.

Author
Pieters R; Schrappe M; De Lorenzo P; Hann I; De Rossi G; Felice M; Hovi L; LeBlanc T; Szczepanski T; Ferster A; Janka G; Rubnitz J; Silverman L; Stary J; Campbell M; Li CK; Mann G; Suppiah R; Biondi A; Vora A; Valsecchi MG;
Institution
Dutch Childhood Oncology Group (DCOG, Netherlands) Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands. rob.pieters@erasmusmc.nl
Journal
Lancet. 2007 Jul 21;370(9583):240-50.
Abstract URL
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8. A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloproliferative disorders.

Author
Karp JE; Giles FJ; Gojo I; Morris L; Greer J; Johnson B; Thein M; Sznol M; Low J;
Institution
Leukemia Program, Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231-1000, USA. jkarp2@jhmi.edu
Journal
Leuk Res. 2008 Jan;32(1):71-7. Epub 2007 Jul 20.
Abstract URL
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9. Non-myeloablative hematopoietic stem cell transplantation is of limited value in advanced or refractory acute myeloblastic leukemia. The Mexican experience.

Author
Gutierrez-Aguirre CH; Cantu-Rodriguez OG; Gonzalez-Llano O; Salazar-Riojas R; Martinez-Gonzalez O; Jaime-Perez JC; Morales-Toquero A; Tarin-Arzaga LC; Ruiz-Arguelles GJ; Gomez-Almaguer D;
Institution
Servicio de Hematologia del Hospital Universitario Dr Jose E. Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, NL, Mexico.
Journal
Hematology. 2007 Jun;12(3):193-7.
Abstract URL
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10. Autologous bone marrow transplantation for children with AML in first remission.

Author
Neudorf S; Sanders J; Kobrinsky N; Alonzo TA; Buxton A; Buckley JD; Howells W; Gold S; Barnard DR; DeSwarte J; Kalousek D; Lange BJ; Woods WG;
Institution
Children's Hospital of Orange County, 455 S. Main Street, Orange, CA 92868, USA. sneudorf@choc.org
Journal
Bone Marrow Transplant. 2007 Aug;40(4):313-8. Epub 2007 Jun 11.
Abstract URL
Click here to view abstract
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