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Currently, with the possible exception of stem cell transplantation in younger patients, there is no know cure for chronic lymphocytic leukemia (CLL). Based on experience gained over the years in managing patients with CLL, doctors have developed the following general principles of treatment:

• Because CLL is a chronic disease, it is often monitored for several years without the need for any treatment intervention.

• In general, treatment is only initiated when there is clinical or laboratory evidence that the disease is progressing to a more advanced stage.

• If treatment is indicated, patients should be offered the opportunity to participate in a clinical trial.

• Patients with CLL who may benefit most from early, aggressive therapy include:

  • younger patients
  • patients in the more advanced stages of CLL
  • patients with adverse prognostic factors

• Patients with CLL are particularly at high risk for developing infections that, in some cases, may be life-threatening. The prevention and treatment of infections, therefore, is a primary goal in the management of patients with CLL.