Previous Section
Introduction to Multiple Myeloma
What Causes Multiple Myeloma?
The exact cause of multiple myeloma is unknown. In some cases, multiple myeloma is preceeded by a condition known as monoclonal gammopathy of undetermined significance (MGUS). Like multiple myeloma, MGUS is characterized by the uncontrolled growth of plasma cells in the bone marrow and the overproduction of the M protein monoclonal antibodies. Unlike multiple myeloma, however, MGUS does not produce tumors nor is it associated with any signs or symptoms. The condition is usually detected by a routine blood test for another suspected disease. Approximately 20% of patients with MGUS will eventually develop multiple myeloma or non-Hodgkin's lymphoma. Although people with MGUS do not require treatment for the condition, due to the risk of progression to multiple myeloma or non-Hodgkin's lymphoma, close monitoring of patients with MGUS, to include blood tests and imaging studies, is recommended.
