Friday, August 29, 2008 - 3:20PM EST

Clinical Trials

1. The beneficial effect of chronic graft-versus-host disease on the clinical outcome of transplantation with fludarabine/busulfan-based reduced-intensity conditioning for patients with de novo myelodysplastic syndrome.

Author
Cho BS; Kim YJ; Cho SG; Kim SY; Eom KS; Kim HJ; Lee S; Min CK; Kim DW; Lee JW; Min WS; Kim CC;
Institution
Catholic Hematopoietic Stem Cell Transplantation Center, The Catholic University of Korea, Seoul, Korea.
Journal
Int J Hematol. 2007 Jun;85(5):446-55.
Abstract URL
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2. Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome.

Author
Soriano AO; Yang H; Faderl S; Estrov Z; Giles F; Ravandi F; Cortes J; Wierda WG; Ouzounian S; Quezada A; Pierce S; Estey EH; Issa JP; Kantarjian HM; Garcia-Manero G;
Institution
Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.
Journal
Blood. 2007 Oct 1;110(7):2302-8. Epub 2007 Jun 27.
Abstract URL
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3. Results of a multicenter phase II trial for older patients with c-Kit-positive acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) using low-dose Ara-C and Imatinib.

Author
Heidel F; Cortes J; Rucker FG; Aulitzky W; Letvak L; Kindler T; Huber C; Dohner H; Kantarjian H; Fischer T; Heidel F; Cortes J; Rucker FG; Aulitzky W; Letvak L; Kindler T; Huber C; Dohner H; Kantarjian H; Fischer T;
Institution
Department Internal Medicine III, University-Hospital, Mainz, Germany.
Journal
Cancer. 2007 Mar 1;109(5):907-14.
Abstract URL
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4. The prophylactic effect of itraconazole capsules and fluconazole capsules for systemic fungal infections in patients with acute myeloid leukemia and myelodysplastic syndromes: a Japanese multicenter randomized, controlled study.

Author
Ito Y; Ohyashiki K; Yoshida I; Takeuchi M; Aoyama Y; Mugitani A; Matsuura Y; Wakita H; Matsuda M; Sakamoto E; Kiguchi T; Urabe A; Tamura K; Kanamaru A; Masaoka T; Ito Y; Ohyashiki K; Yoshida I; Takeuchi M; Aoyama Y; Mugitani A; Matsuura Y; Wakita H; Matsuda M; Sakamoto E; Kiguchi T; Urabe A; Tamura K; Kanamaru A; Masaoka T;
Institution
First Department of Internal Medicine (Hematology Division), Tokyo Medical University, Tokyo, Japan. yito@tokyo-med.ac.jp
Journal
Int J Hematol. 2007 Feb;85(2):121-7.
Abstract URL
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5. Allogeneic hematopoietic stem cell transplantation for the treatment of high-risk acute myelogenous leukemia and myelodysplastic syndrome using reduced-intensity conditioning with fludarabine and melphalan.

Author
Oran B; Giralt S; Saliba R; Hosing C; Popat U; Khouri I; Couriel D; Qazilbash M; Anderlini P; Kebriaei P; Ghosh S; Carrasco-Yalan A; de Meis E; Anagnostopoulos A; Donato M; Champlin RE; de Lima M; Oran B; Giralt S; Saliba R; Hosing C; Popat U; Khouri I; Couriel D; Qazilbash M; Anderlini P; Kebriaei P; Ghosh S; Carrasco-Yalan A; de Meis E; Anagnostopoulos A; Donato M; Champlin RE; de Lima M;
Institution
M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Journal
Biol Blood Marrow Transplant. 2007 Apr;13(4):454-62. Epub 2007 Feb 8.
Abstract URL
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6. Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: chronic graft-versus-host disease is the strongest factor improving survival.

Author
Valcarcel D; Martino R; Caballero D; Martin J; Ferra C; Nieto JB; Sampol A; Bernal MT; Pinana JL; Vazquez L; Ribera JM; Besalduch J; Moraleda JM; Carrera D; Brunet MS; Perez-Simon JA; Sierra J; Valcarcel D; Martino R; Caballero D; Martin J; Ferra C; Nieto JB; Sampol A; Bernal MT; Pinana JL; Vazquez L; Ribera JM; Besalduch J; Moraleda JM; Carrera D; Brunet MS; Perez-Simon JA; Sierra J;
Institution
Hospital de la Santa Creu i Sant Pau, Universitat Autonoma Barcelona, Barcelona, Spain. dvalcarcel@santpau.es
Journal
J Clin Oncol. 2008 Feb 1;26(4):577-84. Epub 2007 Dec 17.
Abstract URL
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7. Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia.

Author
Frankel A; Liu JS; Rizzieri D; Hogge D; Frankel A; Liu JS; Rizzieri D; Hogge D;
Institution
Scott & White Cancer Research Institute, Temple, TX, USA.
Journal
Leuk Lymphoma. 2008 Mar;49(3):543-53.
Abstract URL
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8. Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes.

Author
Siitonen T; Timonen T; Juvonen E; Terava V; Kutila A; Honkanen T; Mikkola M; Hallman H; Kauppila M; Nylanden P; Poikonen E; Rauhala A; Sinisalo M; Suominen M; Savolainen ER; Koistinen P;
Institution
Department of Internal Medicine, Oulu University Hospital, OYS, Finland. timo.siitonen@ppshp.fi
Journal
Haematologica. 2007 Aug;92(8):1119-22.
Abstract URL
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9. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes.

Author
Malcovati L; Germing U; Kuendgen A; Della Porta MG; Pascutto C; Invernizzi R; Giagounidis A; Hildebrandt B; Bernasconi P; Knipp S; Strupp C; Lazzarino M; Aul C; Cazzola M;
Institution
Department of Hematology, University of Pavia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy.
Journal
J Clin Oncol. 2007 Aug 10;25(23):3503-10.
Abstract URL
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10. Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1 risk myelodysplastic syndromes with karyotypes other than deletion 5q.

Author
Raza A; Reeves JA; Feldman EJ; Dewald GW; Bennett JM; Deeg HJ; Dreisbach L; Schiffer CA; Stone RM; Greenberg PL; Curtin PT; Klimek VM; Shammo JM; Thomas D; Knight RD; Schmidt M; Wride K; Zeldis JB; List AF;
Institution
Rush University Medical Center, Chicago, IL, USA.
Journal
Blood. 2008 Jan 1;111(1):86-93. Epub 2007 Sep 24.
Abstract URL
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