Wednesday, December 3, 2008 - 1:52AM EST

New Developments in Graves' Disease

  • Newer, less invasive surgical procedures are being developed for the treatment of Graves' ophthalmopathy.

  • Researchers are studying the long-term safety of orbital radiotherapy for the treatment of Graves' ophthalmopathy.

  • Research is ongoing to identify the optimal management strategies for Graves' disease in children.

  • Research is ongoing to identify the optimal management strategies for Graves' disease during pregnancy.

  • Researchers are studying the impact of smoking on the response to treatment in patients with Graves' ophthalmopathy.

  • Botulinum A toxin injection is being investigated for the treatment of restrictive myopathy of thyroid-related orbitopathy.

  • New drugs being investigated for the treatment of Graves' disease include:

    • Intravenous immunoglobulins
    • Antioxidants (vitamins C and E; beta-carotene; selenium)
    • Cytokine antagonists
    • Colchicine
    • Methotrexate for Graves' ophthalmopathy
    • Short or long-acting sandostatin analogues for Graves' ophthalmopathy
  • Although the cause of Graves' disease is currently unknown, research is ongoing to identify immunological and genetic components that may play a role in the development of this condition. Research in these areas is of critical importance since it may lead to prevention and/or improved methods of treatment for Graves' disease.

  • Information regarding ongoing clinical trials in your area can be obtained at the Clinical Trials Listing Service at http://www.centerwatch.com