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Diabetic Foot Ulcers > What Your Doctor is Reading About Diabetic Foot Ulcers > Clinical Trials

Clinical Trials

1. Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial.

Author: Lipsky BA; Sheehan P; Armstrong DG; Tice AD; Polis AB; Abramson MA;
Institution: Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108-1597, USA. benjamin.lipsiy@med.va.gov
Journal: Int Wound J. 2007 Mar;4(1):30-8.
Abstract URL: Click here to view abstract

2. Negative pressure wound therapy via vacuum-assisted closure following partial foot amputation: what is the role of wound chronicity?

Author: Armstrong DG; Lavery LA; Boulton AJ;
Institution: Scholl's Center for Lower Extremity Ambulatory Research, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA. armstrong@usa.net
Journal: Int Wound J. 2007 Mar;4(1):79-86.
Abstract URL: Click here to view abstract

3. An off-the-shelf instant contact casting device for the management of diabetic foot ulcers: a randomized prospective trial versus traditional fiberglass cast.

Author: Piaggesi A; Macchiarini S; Rizzo L; Palumbo F; Tedeschi A; Nobili LA; Leporati E; Scire V; Teobaldi I; Del Prato S;
Institution: Section of Diabetes and Metabolic Diseases, Department of Endocrinology and Metabolism, University of Pisa and Azienda Ospedaliera Pisana, Pisa, Italy. piaggesi@immr.med.unipi.it
Journal: Diabetes Care. 2007 Mar;30(3):586-90.
Abstract URL: Click here to view abstract

4. Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study.

Author: Fife C; Mader JT; Stone J; Brill L; Satterfield K; Norfleet A; Zwernemann A; Ryaby JT; Carney DH;
Institution: Department of Anesthesiology, University of Texas Health Science Center, Houston, Texas 77555-0645, USA.
Journal: Wound Repair Regen. 2007 Jan-Feb;15(1):23-34.
Abstract URL: Click here to view abstract

5. Does dermal thermometry predict clinical outcome in diabetic foot infection? Analysis of data from the SIDESTEP* trial.

Author: Armstrong DG; Lipsky BA; Polis AB; Abramson MA;
Institution: Rosalind Franklin University, Chicago, IL, USA. Armstrong@usa.net
Journal: Int Wound J. 2006 Dec;3(4):302-7.
Abstract URL: Click here to view abstract

6. Preventing diabetic foot ulcer recurrence in high-risk patients: use of temperature monitoring as a self-assessment tool.

Author: Lavery LA; Higgins KR; Lanctot DR; Constantinides GP; Zamorano RG; Athanasiou KA; Armstrong DG; Agrawal CM;
Institution: Department of Surgery, Scott and White Hospital, Texas A&M University Health Science Center, Temple, Texas, USA. llavery@swmail.org
Journal: Diabetes Care. 2007 Jan;30(1):14-20.
Abstract URL: Click here to view abstract

7. Talactoferrin alfa, a recombinant human lactoferrin promotes healing of diabetic neuropathic ulcers: a phase 1/2 clinical study.

Author: Lyons TE; Miller MS; Serena T; Sheehan P; Lavery L; Kirsner RS; Armstrong DG; Reese A; Yankee EW; Veves A; Lyons TE; Miller MS; Serena T; Sheehan P; Lavery L; Kirsner RS; Armstrong DG; Reese A; Yankee EW; Veves A;
Institution: Beth Israel Deaconess Medical Center and Harvard Medical School, Palmer 321 A, West Campus, Boston, MA 02215, USA.
Journal: Am J Surg. 2007 Jan;193(1):49-54.
Abstract URL: Click here to view abstract

8. Larval therapy: a novel treatment in eliminating methicillin-resistant Staphylococcus aureus from diabetic foot ulcers.

Author: Bowling FL; Salgami EV; Boulton AJ;
Institution: University Department of Medicine and Diabetes, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U.K. frank.bowling@manchester.ac.uk
Journal: Diabetes Care. 2007 Feb;30(2):370-1.

9. Prospective randomized controlled study of Hydrofiber dressing containing ionic silver or calcium alginate dressings in non-ischaemic diabetic foot ulcers.

Author: Jude EB; Apelqvist J; Spraul M; Martini J;
Institution: Department of Diabetic Medicine, Tameside General Hospital, Ashton-Under-Lyne, UK. edward.jude@tgh.nhs.uk
Journal: Diabet Med. 2007 Mar;24(3):280-8.
Abstract URL: Click here to view abstract

10. Evaluation of Bensal HP for the treatment of diabetic foot ulcers.

Author: Jacobs AM; Tomczak R;
Institution: Caribbean Medical University, Piscadera Bay, Curacao, Netherlands Antilles.
Journal: Adv Skin Wound Care. 2008 Oct;21(10):461-5.
Abstract URL: Click here to view abstract

11. Intermittent intravenous urokinase for critical limb ischemia in diabetic foot ulceration.

Author: Weck M; Rietzsch H; Lawall H; Pichlmeier U; Bramlage P; Schellong S;
Institution: Clinic Bavaria, Dept. Diabetes, Metabolism and Endocrinology, Kreischa, Germany.
Journal: Thromb Haemost. 2008 Sep;100(3):475-82.
Abstract URL: Click here to view abstract

12. Education for secondary prevention of foot ulcers in people with diabetes: a randomised controlled trial.

Author: Lincoln NB; Radford KA; Game FL; Jeffcoate WJ;
Institution: Institute of Work, Health and Organisations, University of Nottingham, Nottingham, UK.
Journal: Diabetologia. 2008 Nov;51(11):1954-61. Epub 2008 Aug 30.
Abstract URL: Click here to view abstract

13. The influence of local versus global heat on the healing of chronic wounds in patients with diabetes.

Author: Petrofsky JS; Lawson D; Suh HJ; Rossi C; Zapata K; Broadwell E; Littleton L;
Institution: Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, California 92350, USA. jpetrofsky@llu.edu
Journal: Diabetes Technol Ther. 2007 Dec;9(6):535-44.
Abstract URL: Click here to view abstract

14. Wound healing: total contact cast vs. custom-made temporary footwear for patients with diabetic foot ulceration.

Author: Van De Weg FB; Van Der Windt DA; Vahl AC;
Institution: Rehabilitation Centre Amsterdam, Amsterdam, The Netherlands. f.b.vandeweg@olvg.nl
Journal: Prosthet Orthot Int. 2008 Mar;32(1):3-11.
Abstract URL: Click here to view abstract

15. Randomized, controlled, single-blind study on use of autologous keratinocytes on a transfer dressing to treat nonhealing diabetic ulcers.

Author: Moustafa M; Bullock AJ; Creagh FM; Heller S; Jeffcoate W; Game F; Amery C; Tesfaye S; Ince Z; Haddow DB; MacNeil S;
Institution: Northern General Hospital, Division of Clinical Sciences (North), School of Medicine, Sheffield, S5 7AU, UK.
Journal: Regen Med. 2007 Nov;2(6):887-902.
Abstract URL: Click here to view abstract

16. Unsuspected osteomyelitis is frequent in persistent diabetic foot ulcer and better diagnosed by MRI than by 18F-FDG PET or 99mTc-MOAB.

Author: Schwegler B; Stumpe KD; Weishaupt D; Strobel K; Spinas GA; von Schulthess GK; Hodler J; Boni T; Donath MY;
Institution: Clinic for Endocrinology and Diabetes, University Hospital, Zurich, Switzerland.
Journal: J Intern Med. 2008 Jan;263(1):99-106. Epub 2007 Nov 23.
Abstract URL: Click here to view abstract

17. Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers.

Author: Hanft JR; Pollak RA; Barbul A; van Gils C; Kwon PS; Gray SM; Lynch CJ; Semba CP; Breen TJ;
Institution: Doctor's Research Network, South Miami, Florida, USA.
Journal: J Wound Care. 2008 Jan;17(1):30-2, 34-7.
Abstract URL: Click here to view abstract

18. The football: an intuitive dressing for offloading neuropathic plantar forefoot ulcerations.

Author: Rader AJ; Barry TP;
Institution: Memorial Hospital and Healthcare Center, The Wound Care Center St Mary's Healthcare Center, Diabetic Foot Clinic, Jasper, IN 47546, USA. pvppc@fullnet.com
Journal: Int Wound J. 2008 Mar;5(1):69-73. Epub 2008 Jan 3.
Abstract URL: Click here to view abstract

19. Skin temperature monitoring reduces the risk for diabetic foot ulceration in high-risk patients.

Author: Armstrong DG; Holtz-Neiderer K; Wendel C; Mohler MJ; Kimbriel HR; Lavery LA;
Institution: Scholl's Center for Lower Extremity Ambulatory Research (CLEAR), Rosalind Franklin University of Medicine and Science, North Chicago, Ill 60064, USA. armstrong@usa.net
Journal: Am J Med. 2007 Dec;120(12):1042-6.
Abstract URL: Click here to view abstract

20. Phagocytic activity of neutrophils improves over the course of therapy of diabetic foot infections.

Author: Top C; Yildiz S; Oncul O; Qydedi T; Cevikbas A; Soyogul UG; Cavuslu S;
Institution: Department of Internal Medicine, Gulhane Military Medical Academy, GATA Haydarpasa Training Hospital, Tibbiye Cad. 81327 Haydarpasa, Istanbul, Turkey. tpcihan@hotmail.com
Journal: J Infect. 2007 Oct;55(4):369-73. Epub 2007 Aug 2.
Abstract URL: Click here to view abstract

21. Risk of plantar ulceration in diabetic patients with single-leg amputation.

Author: Kanade RV; van Deursen RW; Price P; Harding K;
Institution: Research Centre for Clinical Kinaesiology, Department of Physiotherapy, School of Healthcare Studies, Cardiff University, Ty Dewi Sant, Health Park, Cardiff CF14 4XN, United Kingdom.
Journal: Clin Biomech (Bristol, Avon). 2006 Mar;21(3):306-13. Epub 2005 Nov 28.
Abstract URL: Click here to view abstract

22. Effectiveness of recombinant human platelet-derived growth factor for the treatment of diabetic neuropathic foot ulcers.

Author: Margolis DJ; Bartus C; Hoffstad O; Malay S; Berlin JA;
Institution: Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. dmargoli@cceb.med.upenn.edu
Journal: Wound Repair Regen. 2005 Nov-Dec;13(6):531-6.
Abstract URL: Click here to view abstract

23. Ultrasound therapy for recalcitrant diabetic foot ulcers: results of a randomized, double-blind, controlled, multicenter study.

Author: Ennis WJ; Foremann P; Mozen N; Massey J; Conner-Kerr T; Meneses P;
Institution: Wound Treatment Program, Advocate Christ Medical Center, 4440 West 95th Street, Oak Lawn, IL 60453, USA. wtc211@pol.net
Journal: Ostomy Wound Manage. 2005 Aug;51(8):24-39.
Abstract URL: Click here to view abstract

24. Quality of life and clinical correlates in patients with diabetic foot ulcers.

Author: Valensi P; Girod I; Baron F; Moreau-Defarges T; Guillon P;
Institution: Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, Paris-Nord University, Bondy, France. paul.valensi@jvr.ap-hop-paris.fr
Journal: Diabetes Metab. 2005 Jun;31(3 Pt 1):263-71.
Abstract URL: Click here to view abstract

25. Recombinant human epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers.

Author: Hong JP; Jung HD; Kim YW;
Institution: Department of Plastic and Reconstructive Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. joonphong@amc.seoul.kr
Journal: Ann Plast Surg. 2006 Apr;56(4):394-8; discussion 399-400.
Abstract URL: Click here to view abstract

26. Effect of window casts on healing rates of diabetic foot ulcers.

Author: Agas CM; Bui TD; Driver VR; Gordon IL;
Institution: VA Long Beach Healthcare System, Department of Vascular Surgery, California, USA.
Journal: J Wound Care. 2006 Feb;15(2):80-3.

27. Sustained silver-releasing dressing in the treatment of diabetic foot ulcers.

Author: Rayman G; Rayman A; Baker NR; Jurgeviciene N; Dargis V; Sulcaite R; Pantelejeva O; Harding KG; Price P; Lohmann M; Thomsen JK; Gad P; Gottrup F;
Institution: Diabetic Foot Research Office, The Ipswich Hospital NHS Trust, Ipswich UK.
Journal: Br J Nurs. 2005 Jan 27-Feb 9;14(2):109-14.
Abstract URL: Click here to view abstract

28. A randomized trial of two irremovable off-loading devices in the management of plantar neuropathic diabetic foot ulcers.

Author: Katz IA; Harlan A; Miranda-Palma B; Prieto-Sanchez L; Armstrong DG; Bowker JH; Mizel MS; Boulton AJ;
Institution: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, DRI Building, 1450 N.W. 10th Ave., Room 3054, P.O. Box 016960 (D110), Miami, FL 33101, USA. irakatz@bellsouth.net
Journal: Diabetes Care. 2005 Mar;28(3):555-9.
Abstract URL: Click here to view abstract

29. Healing diabetic neuropathic foot ulcers: are we getting better?

Author: Margolis DJ; Allen-Taylor L; Hoffstad O; Berlin JA;
Institution: Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. dmargoli@cceb.med.upenn.edu
Journal: Diabet Med. 2005 Feb;22(2):172-6.
Abstract URL: Click here to view abstract

30. An open-label, randomized study comparing efficacy and safety of intravenous piperacillin/tazobactam and ampicillin/sulbactam for infected diabetic foot ulcers.

Author: Harkless L; Boghossian J; Pollak R; Caputo W; Dana A; Gray S; Wu D;
Institution: University of Texas Health Science Center, UCCH/Texas Diabetes Institute, San Antonio, Texas, USA.
Journal: Surg Infect (Larchmt). 2005 Spring;6(1):27-40.
Abstract URL: Click here to view abstract

31. Health-related quality of life of diabetic foot ulcer patients and their caregivers.

Author: Nabuurs-Franssen MH; Huijberts MS; Nieuwenhuijzen Kruseman AC; Willems J; Schaper NC;
Institution: Division of Endocrinology, Department of Internal Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands. marrigje.nabuurs@gmail.com
Journal: Diabetologia. 2005 Sep;48(9):1906-10. Epub 2005 Jul 2.
Abstract URL: Click here to view abstract

32. Diabetic neuropathic foot ulcers and amputation.

Author: Margolis DJ; Allen-Taylor L; Hoffstad O; Berlin JA;
Institution: Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. dmargoli@cceb.med.upenn.edu
Journal: Wound Repair Regen. 2005 May-Jun;13(3):230-6.
Abstract URL: Click here to view abstract

33. Can the use of a topical antifungal nail lacquer reduce risk for diabetic foot ulceration? Results from a randomised controlled pilot study.

Author: Armstrong DG; Holtz K; Wu S;
Institution: Scholl's Center for Lower Extremity Ambulatory Research (CLEAR) at Rosalind Franklin University of Medicine, 3333 Green Bay Road, Chicago, IL 60064, USA. armstrong@usa.net
Journal: Int Wound J. 2005 Jun;2(2):166-70.
Abstract URL: Click here to view abstract

34. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers.

Author: Driver VR; Hanft J; Fylling CP; Beriou JM; Autologel Diabetic Foot Ulcer Study Group;
Institution: Cytomedix, Inc., 416 Hungerford Drive, Rockville, MD 20850, USA.
Journal: Ostomy Wound Manage. 2006 Jun;52(6):68-70, 72, 74 passim.
Abstract URL: Click here to view abstract