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Clinical Trials

1. Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson's disease.

Author: Agostino R; Dinapoli L; Modugno N; Iezzi E; Romanelli P; Berardelli A;
Institution: Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy.
Journal: J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):76-8. Epub 2007 Aug 6.
Abstract URL: Click here to view abstract

2. Exhaustive, one-year follow-up of subthalamic nucleus deep brain stimulation in a large, single-center cohort of parkinsonian patients.

Author: Tir M; Devos D; Blond S; Touzet G; Reyns N; Duhamel A; Cottencin O; Dujardin K; Cassim F; Destee A; Defebvre L; Krystkowiak P;
Institution: Department of Neurology, Salengro Hospital, Lille University Medical Centre, Lille, France.
Journal: Neurosurgery. 2007 Aug;61(2):297-304; discussion 304-5.
Abstract URL: Click here to view abstract

3. Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson's disease.

Author: York MK; Dulay M; Macias A; Levin HS; Grossman R; Simpson R; Jankovic J;
Institution: Baylor College of Medicine, Department of Neurology, 6501 Fannin, NB302, Houston, Texas 77030, USA. myork@bcm.edu
Journal: J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):789-95. Epub 2007 Oct 26.
Abstract URL: Click here to view abstract

4. Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease.

Author: Tabbal SD; Revilla FJ; Mink JW; Schneider-Gibson P; Wernle AR; de Erausquin GA; Perlmutter JS; Rich KM; Dowling JL;
Institution: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. tabbals@neuro.wustl.edu
Journal: Neurosurgery. 2007 Sep;61(3 Suppl):119-27; discussion 127-9.
Abstract URL: Click here to view abstract

5. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.

Author: Kaplitt MG; Feigin A; Tang C; Fitzsimons HL; Mattis P; Lawlor PA; Bland RJ; Young D; Strybing K; Eidelberg D; During MJ;
Institution: Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY, USA.
Journal: Lancet. 2007 Jun 23;369(9579):2097-105.
Abstract URL: Click here to view abstract

6. Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.

Author: Eberling JL; Jagust WJ; Christine CW; Starr P; Larson P; Bankiewicz KS; Aminoff MJ;
Institution: Department of Molecular Imaging and Neuroscience, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. jleberling@lbl.gov
Journal: Neurology. 2008 May 20;70(21):1980-3. Epub 2008 Apr 9.
Abstract URL: Click here to view abstract

7. Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease.

Author: Watts RL; Jankovic J; Waters C; Rajput A; Boroojerdi B; Rao J;
Institution: Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233-0017, USA. rlwatts@uab.edu
Journal: Neurology. 2007 Jan 23;68(4):272-6. Epub 2007 Jan 3.
Abstract URL: Click here to view abstract

8. Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study.

Author: Murata M; Hasegawa K; Kanazawa I;
Institution: Department of Neurology, Musashi Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo 187-8551, Japan. mihom@ncnp.go.jp
Journal: Neurology. 2007 Jan 2;68(1):45-50.
Abstract URL: Click here to view abstract

9. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease.

Author
Institution: University of Rochester Medical Center, 1351 Mt. Hope Ave., Ste. 223, Rochester, NY 14620, USA.
Journal: Neurology. 2007 Jan 2;68(1):20-8.
Abstract URL: Click here to view abstract

10. Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial.

Author: Schupbach WM; Maltete D; Houeto JL; du Montcel ST; Mallet L; Welter ML; Gargiulo M; Behar C; Bonnet AM; Czernecki V; Pidoux B; Navarro S; Dormont D; Cornu P; Agid Y;
Institution: Centre d'Investigation Clinique, Groupe Hospitalier Pitie-Salpetriere, Paris, France.
Journal: Neurology. 2007 Jan 23;68(4):267-71. Epub 2006 Dec 6.
Abstract URL: Click here to view abstract

11. A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson's disease.

Author: Ashburn A; Fazakarley L; Ballinger C; Pickering R; McLellan LD; Fitton C;
Institution: Rehabilitation Research Unit, School of Health Professions and Rehabilitation Sciences, University of Southampton, Level E, Centre Block, Mailpoint 886, Southampton General Hospital, Tremona Rd, Southampton SO16 6YD, UK. ann@soton.ac.uk
Journal: J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):678-84. Epub 2006 Nov 21.
Abstract URL: Click here to view abstract

12. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease.

Author: Storch A; Jost WH; Vieregge P; Spiegel J; Greulich W; Durner J; Muller T; Kupsch A; Henningsen H; Oertel WH; Fuchs G; Kuhn W; Niklowitz P; Koch R; Herting B; Reichmann H; Storch A; Jost WH; Vieregge P; Spiegel J; Greulich W; Durner J; Muller T; Kupsch A; Henningsen H; Oertel WH; Fuchs G; Kuhn W; Niklowitz P; Koch R; Herting B; Reichmann H;
Institution: Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Alexander.Storch@neuro.med.tu-dresden.de
Journal: Arch Neurol. 2007 Jul;64(7):938-44. Epub 2007 May 14.
Abstract URL: Click here to view abstract

13. Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial.

Author: Poewe WH; Rascol O; Quinn N; Tolosa E; Oertel WH; Martignoni E; Rupp M; Boroojerdi B;
Institution: Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Journal: Lancet Neurol. 2007 Jun;6(6):513-20.
Abstract URL: Click here to view abstract

14. Transdermal rotigotine: double-blind, placebo-controlled trial in Parkinson disease.

Author: Jankovic J; Watts RL; Martin W; Boroojerdi B;
Institution: Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA. josephj@bcm.tmc.edu
Journal: Arch Neurol. 2007 May;64(5):676-82.
Abstract URL: Click here to view abstract

15. Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of 'off' episodes in patients with Parkinson's disease.

Author: Lew MF; Pahwa R; Leehey M; Bertoni J; Kricorian G;
Institution: Keck/University of Southern California School of Medicine, Los Angeles, CA 90033, USA. marklew@usc.edu
Journal: Curr Med Res Opin. 2007 Apr;23(4):741-50.
Abstract URL: Click here to view abstract

16. Ropinirole 24-hour prolonged release: randomized, controlled study in advanced Parkinson disease.

Author: Pahwa R; Stacy MA; Factor SA; Lyons KE; Stocchi F; Hersh BP; Elmer LW; Truong DD; Earl NL;
Institution: University of Kansas Medical Center, Kansas City, KS 66160, USA. rpahwa@kumc.edu
Journal: Neurology. 2007 Apr 3;68(14):1108-15.
Abstract URL: Click here to view abstract

17. Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.

Author: Sato Y; Honda Y; Iwamoto J; Sato Y; Honda Y; Iwamoto J;
Institution: Department of Neurology, Mitate Hospital, 3237 Yugeta, Tagawa 826-0041, Japan. y-sato@ktarn.or.jp
Journal: Neurology. 2007 Mar 20;68(12):911-5.
Abstract URL: Click here to view abstract

18. Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal.

Author: Slevin JT; Gash DM; Smith CD; Gerhardt GA; Kryscio R; Chebrolu H; Walton A; Wagner R; Young AB;
Institution: Department of Neurology, University of Kentucky, Chandler Medical Center, Lexington, Kentucky 40536-0284, USA. slevin@uky.edu
Journal: J Neurosurg. 2007 Apr;106(4):614-20.
Abstract URL: Click here to view abstract

19. Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study.

Author: LeWitt PA; Lyons KE; Pahwa R;
Institution: Clinical Neuroscience Center, Southfield, MI 48034, USA. palewitt@ameritech.net
Journal: Neurology. 2007 Apr 17;68(16):1262-7.
Abstract URL: Click here to view abstract

20. Unilateral deep brain stimulation of the subthalamic nucleus for Parkinson disease.

Author: Slowinski JL; Putzke JD; Uitti RJ; Lucas JA; Turk MF; Kall BA; Wharen RE;
Institution: Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida 32224, USA.
Journal: J Neurosurg. 2007 Apr;106(4):626-32.
Abstract URL: Click here to view abstract