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Symptoms of peripheral neuropathy (PN) usually begin gradually and may barely be noticeable when they first appear. Initial sensations may be intermittent and can include tingling, numbness, or other feelings in the feet/toes or hands/fingers. Symptoms usually progress from the periphery towards the center of the body. Some individuals experience intensification of their symptoms at night.

Skin may become increasingly sensitive and the slightest touch can cause excruciating pain. Many people have pain or burning distributed in the pattern of wearing an invisible sock or glove. The pain or sensations can increase in frequency and duration and can also change in quality to include new symptoms. Each individual can have a unique pattern of pain progression.

If motor nerves are involved, the individual may experience weakness in the legs or arms and a sense of heaviness when trying to lift them. This also effects balance and increases the danger of falling and fracture. If autonomic nerves are involved, the individual may progress to having related symptoms (e.g., bowel or bladder problems, impotence, cardiac symptoms and/or reduced sweating).