Sunday, September 7, 2008 - 1:55PM EST

Clinical Trials

1. Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial.

Author
Trenkwalder C; Benes H; Grote L; Happe S; Hogl B; Mathis J; Saletu-Zyhlarz GM; Kohnen R;
Institution
Paracelsus-Elena Hospital, University of Gottingen, Kassel, Germany. ctrenkwalder@gmx.de
Journal
Mov Disord. 2007 Apr 15;22(5):696-703.
Abstract URL
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2. The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trial.

Author
Merlino G; Dolso P; Canesin R; Cancelli I; Valente M; Gigli GL;
Institution
Sleep Disorder Centre, Department of Neurology, Santa Maria della Misericordia University Hospital, Udine, Italy.
Journal
Neuropsychobiology. 2006;54(3):195-200. Epub 2007 Feb 21.
Abstract URL
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3. Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II, randomized, double-blind, placebo-controlled, dose-response study.

Author
Garcia-Borreguero D; Winkelman J; Adams A; Ellis A; Morris M; Lamb J; Layton G; Versavel M;
Institution
Department of Neurology, Fundacion Jimenez Diaz, Sleep Disorders Unit, Universidad Autonoma de Madrid, Madrid, Spain. dgb@iis.es
Journal
Sleep Med. 2007 Mar;8(2):119-27. Epub 2007 Jan 18.
Abstract URL
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4. Sequential compression devices for treatment of restless legs syndrome.

Author
Eliasson AH; Lettieri CJ;
Institution
Pulmonary and Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. arn.eliasson@us.army.mil
Journal
Medicine (Baltimore). 2007 Nov;86(6):317-23.
Abstract URL
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5. A 52-week open-label study of the long-term safety of ropinirole in patients with restless legs syndrome.

Author
Garcia-Borreguero D; Grunstein R; Sridhar G; Dreykluft T; Montagna P; Dom R; Lainey E; Moorat A; Roberts J; Garcia-Borreguero D; Grunstein R; Sridhar G; Dreykluft T; Montagna P; Dom R; Lainey E; Moorat A; Roberts J;
Institution
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain. dgb@iis.es
Journal
Sleep Med. 2007 Nov;8(7-8):742-52. Epub 2007 May 18.
Abstract URL
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6. Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome.

Author
Garcia-Borreguero D; Kohnen R; Hogl B; Ferini-Strambi L; Hadjigeorgiou GM; Hornyak M; de Weerd AW; Happe S; Stiasny-Kolster K; Gschliesser V; Egatz R; Cabrero B; Frauscher B; Trenkwalder C; Hening WA; Allen RP;
Institution
Fundacion Jimenez Diaz, Madrid, Spain. dgb@iis.es
Journal
Sleep Med. 2007 Aug;8(5):455-63. Epub 2007 May 31.
Abstract URL
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7. Ropinirole in the treatment of patients with restless legs syndrome: a US-based randomized, double-blind, placebo-controlled clinical trial.

Author
Bogan RK; Fry JM; Schmidt MH; Carson SW; Ritchie SY;
Institution
SleepMed of South Carolina, 1333 Taylor St, Columbia, SC 29201, USA. rbogan@sleepmed.md
Journal
Mayo Clin Proc. 2006 Jan;81(1):17-27.
Abstract URL
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8. Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome.

Author
Bliwise, D L; Freeman, A; Ingram, C D; Rye DB; Chakravorty, S; Watts, R L;
Institution
Department of Neurology, Emory University Medical School, WMRB, Suite 6000, 1639 Pierce Drive, Atlanta, GA 30322, USA. dbliwis@emory.edu
Journal
Sleep Med. 2005 Mar;6(2):141-7.
Abstract URL
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9. Ropinirole in the treatment of restless legs syndrome.

Author
Thorpy, Michael;
Institution
Journal
Curr Neurol Neurosci Rep. 2005 Mar;5(2):137-9.

10. Treatment of Japanese restless legs syndrome patients with cabergoline: an open clinical preliminary trial.

Author
Aizawa H; Aburakawa Y; Suzuki Y; Enomoto H; Makita Y; Kikuchi K; Kimura T; Yahara O;
Institution
First Department of Medicine, Asahikawa Medical College, Asahikawa.
Journal
Intern Med. 2006 Jul;45(7):453-5. Epub 2006 May 1.
Abstract URL
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