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Clinical Trials

1. Efficacy and patterns of failure for locally advanced cancer of the cervix treated with celebrex (celecoxib) and chemoradiotherapy in RTOG 0128.

Author: Gaffney DK; Winter K; Dicker AP; Miller B; Eifel PJ; Ryu J; Avizonis V; Fromm M; Small W; Greven K;
Institution: Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84132, USA. david.gaffney@hci.utah
Journal: Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):111-7. Epub 2007 May 4.
Abstract URL: Click here to view abstract

2. Treatment of ("bulky") stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: a phase III trial of the gynecologic oncology group.

Author: Eddy GL; Bundy BN; Creasman WT; Spirtos NM; Mannel RS; Hannigan E; O'Connor D;
Institution: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mercer University School of Medicine, 840 Pine Street, Suite 760, Macon, GA 31201, USA. eddy.gary@mccg.org
Journal: Gynecol Oncol. 2007 Aug;106(2):362-9. Epub 2007 May 9.
Abstract URL: Click here to view abstract

3. Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study.

Author: Rose PG; Ali S; Watkins E; Thigpen JT; Deppe G; Clarke-Pearson DL; Insalaco S;
Institution: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Journal: J Clin Oncol. 2007 Jul 1;25(19):2804-10. Epub 2007 May 14.
Abstract URL: Click here to view abstract

4. Heat shock fusion protein-based immunotherapy for treatment of cervical intraepithelial neoplasia III.

Author: Einstein MH; Kadish AS; Burk RD; Kim MY; Wadler S; Streicher H; Goldberg GL; Runowicz CD;
Institution: Albert Einstein College of Medicine, and Albert Einstein Cancer Center, Bronx, NY 10461, USA. meinstei@montefiore.org
Journal: Gynecol Oncol. 2007 Sep;106(3):453-60. Epub 2007 Jun 22.
Abstract URL: Click here to view abstract

5. A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia.

Author: Roman LD; Wilczynski S; Muderspach LI; Burnett AF; O'Meara A; Brinkman JA; Kast WM; Facio G; Felix JC; Aldana M; Weber JS;
Institution: Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. lroman@hsc.usc.edu
Journal: Gynecol Oncol. 2007 Sep;106(3):558-66. Epub 2007 Jul 12.
Abstract URL: Click here to view abstract

6. Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005).

Author: Ryu HS; Kang SB; Kim KT; Chang KH; Kim JW; Kim JH;
Institution: Department of Obstetrics and Gynecology, School of Medicine, Ajou University, Suwon, Korea.
Journal: Int J Gynecol Cancer. 2007 Jan-Feb;17(1):132-6.
Abstract URL: Click here to view abstract

7. Ovarian metastases in early-stage cervical cancer (IA2-IIA): a multicenter retrospective study of 1965 patients (a Cooperative Task Force study).

Author: Landoni F; Zanagnolo V; Lovato-Diaz L; Maneo A; Rossi R; Gadducci A; Cosio S; Maggino T; Sartori E; Tisi C; Zola P; Marocco F; Botteri E; Ravanelli K;
Institution: Department of Gynecology Oncology, European Institute of Oncology (EIO), Milan, Italy. fabio.landoni@ieo.it
Journal: Int J Gynecol Cancer. 2007 May-Jun;17(3):623-8. Epub 2007 Feb 16.
Abstract URL: Click here to view abstract

8. Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours.

Author: Viswanathan AN; Dimopoulos J; Kirisits C; Berger D; Potter R;
Institution: Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA, USA.
Journal: Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):491-8. Epub 2007 Feb 27.
Abstract URL: Click here to view abstract

9. Phase II study of consolidation chemotherapy after concurrent chemoradiation in cervical cancer: preliminary results.

Author: Choi CH; Lee JW; Kim TJ; Kim WY; Nam HR; Kim BG; Huh SJ; Lee JH; Bae DS;
Institution: Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Journal: Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):817-22. Epub 2007 Mar 26.
Abstract URL: Click here to view abstract

10. Weekly low-dose paclitaxel and carboplatin in the treatment of advanced or recurrent cervical and endometrial cancer.

Author: Secord AA; Havrilesky LJ; Carney ME; Soper JT; Clarke-Pearson DL; Rodriguez GC; Berchuck A;
Institution: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Box 3079, Duke University Medical Center, Durham, NC 27710, USA. secor002@mc.duke.edu
Journal: Int J Clin Oncol. 2007 Feb;12(1):31-6. Epub 2007 Feb 25.
Abstract URL: Click here to view abstract

11. Phase II clinical trial of docetaxel in refractory squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study.

Author: Garcia AA; Blessing JA; Vaccarello L; Roman LD;
Institution: Premiere Oncology, Santa Monica, CA, USA.
Journal: Am J Clin Oncol. 2007 Aug;30(4):428-31.
Abstract URL: Click here to view abstract

12. Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial.

Author: Franckena M; Stalpers LJ; Koper PC; Wiggenraad RG; Hoogenraad WJ; van Dijk JD; Warlam-Rodenhuis CC; Jobsen JJ; van Rhoon GC; van der Zee J;
Institution: Department of Radiation Oncology, Hyperthermia Unit, Erasmus Medical Center Rotterdam, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. m.franckena@erasmusmc.nl
Journal: Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1176-82. Epub 2007 Sep 19.
Abstract URL: Click here to view abstract

13. Cervical cancer associated with pregnancy: results of a multicenter retrospective Korean study (KGOG-1006).

Author: Lee JM; Lee KB; Kim YT; Ryu HS; Kim YT; Cho CH; Namkoong SE; Lee KH; Choi HS; Kim KT;
Institution: Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyung Hee University, Seoul, Korea.
Journal: Am J Obstet Gynecol. 2008 Jan;198(1):92.e1-6. Epub 2007 Oct 1.
Abstract URL: Click here to view abstract

14. Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer.

Author: Kim YS; Shin SS; Nam JH; Kim YT; Kim YM; Kim JH; Choi EK;
Institution: Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Journal: Gynecol Oncol. 2008 Jan;108(1):195-200. Epub 2007 Oct 25.
Abstract URL: Click here to view abstract

15. A phase II trial to evaluate gefitinib as second- or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer.

Author: Goncalves A; Fabbro M; Lhomme C; Gladieff L; Extra JM; Floquet A; Chaigneau L; Carrasco AT; Viens P;
Institution: Institut Paoli Calmettes, UFR Medecine-Universite de la Mediterranee, Marseille, France.
Journal: Gynecol Oncol. 2008 Jan;108(1):42-6. Epub 2007 Nov 5.
Abstract URL: Click here to view abstract

16. Dilution of dye improves parametrial SLN detection in patients with cervical cancer.

Author: Altgassen C; Paseka A; Urbanczyk H; Dimpfl T; Diedrich K; Dahmen G; Hertel H;
Institution: Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Luebeck, Germany. altgassen@frauenklinik.uni-luebeck.de
Journal: Gynecol Oncol. 2007 May;105(2):329-34. Epub 2007 Jan 19.
Abstract URL: Click here to view abstract

17. The effects of bethanechol and cisapride on urodynamic parameters in patients undergoing radical hysterectomy for cervical cancer. A randomized, double-blind, placebo-controlled study.

Author: Madeiro AP; Rufino AC; Sartori MG; Baracat EC; Lima GR; Girao MJ;
Institution: Sao Marcos Hospital, Piaui Cancer Society, Av. Cel. Costa Araujo, 3033, Horto Florestal, Teresina, Piaui, 64049 460, Brazil. madeiro@uol.com.br
Journal: Int Urogynecol J Pelvic Floor Dysfunct. 2006 May;17(3):248-52. Epub 2005 Jun 14.
Abstract URL: Click here to view abstract

18. Carboplatin-based neoadjuvant treatment with peripheral blood stem cell and growth factor support in locally advanced cervical cancer patients with bulky metastatic lymph nodes.

Author: Ferrandina G; Perillo A; Distefano M; D'Agostino G; Gallotta V; Pierelli L; Scambia G;
Institution
Journal: Eur J Obstet Gynecol Reprod Biol. 2007 Apr;131(2):236-8. Epub 2006 May 2.

19. Radical vaginal trachelectomy (RVT) combined with laparoscopic pelvic lymphadenectomy: prospective multicenter study of 100 patients with early cervical cancer.

Author: Hertel H; Kohler C; Grund D; Hillemanns P; Possover M; Michels W; Schneider A;
Institution: Department of Gynecology, Medical School Hanover, Germany.
Journal: Gynecol Oncol. 2006 Nov;103(2):506-11. Epub 2006 May 11.
Abstract URL: Click here to view abstract

20. Apoptosis in cervical cancer after balloon-occluded arterial infusion of anticancer drugs.

Author: Kokawa K; Mabuchi Y; Tanaka K; Yagi S; Utsunomiya T; Oba N; Yata C; Umesaki N;
Institution: Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641-0012, Japan. katsu@wakayama-med.ac.jp
Journal: Anticancer Res. 2006 Mar-Apr;26(2B):1413-8.
Abstract URL: Click here to view abstract

21. Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: morbidity and outcome: results of a multicenter study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer).

Author: Classe JM; Rauch P; Rodier JF; Morice P; Stoeckle E; Lasry S; Houvenaeghel G;
Institution: Department of Oncological Surgery, Centre R. Gauducheau, Site Hopital nord, Bd. J. Monod, 44805 Saint-Herblain Nantes, France. jm-classe@nantes.fnclcc.fr
Journal: Gynecol Oncol. 2006 Sep;102(3):523-9. Epub 2006 Feb 28.
Abstract URL: Click here to view abstract

22. Weekly gemcitabine and cisplatin in combination with pelvic radiation in the primary therapy of cervical cancer: a phase I trial of the Puget Sound Oncology Consortium.

Author: Swisher EM; Swensen RE; Greer B; Tamimi H; Goff BA; Garcia R; Koh WJ;
Institution: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, 1959 N.E. Pacific St., Box 356460, Seattle, WA 98195-6460, USA. swishere@u.washington.edu
Journal: Gynecol Oncol. 2006 Jun;101(3):429-35. Epub 2005 Dec 9.
Abstract URL: Click here to view abstract

23. Phase III double-blind randomized trial of radiation therapy for stage IIIb cervical cancer in combination with low- or high-dose Z-100: treatment with immunomodulator, more is not better.

Author: Noda K; Ohashi Y; Sugimori H; Ozaki M; Niibe H; Ogita S; Kohno I; Hasegawa K; Kikuchi Y; Takegawa Y; Fujii S; Tanaka K; Ochiai K; Kita M; Fujiwara K;
Institution: Kinki University, Japan.
Journal: Gynecol Oncol. 2006 Jun;101(3):455-63. Epub 2005 Dec 19.
Abstract URL: Click here to view abstract

24. Quality of life (QOL) outcomes from a randomized trial of cisplatin versus cisplatin plus paclitaxel in advanced cervical cancer: a Gynecologic Oncology Group study.

Author: McQuellon RP; Thaler HT; Cella D; Moore DH;
Institution: Psychosocial Oncology, Comprehensive Cancer Center of Wake Forest University, Department of Internal Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1082, USA. rmcquell@wfubmc.edu
Journal: Gynecol Oncol. 2006 May;101(2):296-304. Epub 2006 Jan 10.
Abstract URL: Click here to view abstract

25. A phase II trial with cisplatin-paclitaxel cytotoxic treatment and concurrent external and endocavitary radiation therapy in locally advanced or recurrent cervical cancer.

Author: Miglietta L; Franzone P; Centurioni MG; Boni L; Tacchini L; Cosso M; Boccardo F; Ferrarini M; Bruzzone M;
Institution: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italia. loredana.miglietta@istge.it
Journal: Oncology. 2006;70(1):19-24. Epub 2006 Jan 26.
Abstract URL: Click here to view abstract

26. Intraarterial cisplatin/nedaplatin and intravenous 5-fluorouracil with concurrent radiation therapy for patients with high-risk uterine cervical cancer.

Author: Kawase S; Okuda T; Ikeda M; Ishihara S; Itoh Y; Yanagawa S; Ishigaki T;
Institution: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya city, Japan.
Journal: Gynecol Oncol. 2006 Sep;102(3):493-9. Epub 2006 Feb 14.
Abstract URL: Click here to view abstract

27. Randomized study of preoperative chemotherapy versus primary surgery for stage IB cervical cancer.

Author: Cai HB; Chen HZ; Yin HH;
Institution: Department of Gynecologic Oncology, Zhong Nan Hospital, Wuhan University, China. chb2105@sohu.com
Journal: J Obstet Gynaecol Res. 2006 Jun;32(3):315-23.
Abstract URL: Click here to view abstract

28. A Phase II study of acute toxicity for Celebrex (celecoxib) and chemoradiation in patients with locally advanced cervical cancer: primary endpoint analysis of RTOG 0128.

Author: Gaffney DK; Winter K; Dicker AP; Miller B; Eifel PJ; Ryu J; Avizonis V; Fromm M; Greven K;
Institution: Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84132, USA. david.gaffney@hci.utah.edu
Journal: Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):104-9. Epub 2006 Nov 2.
Abstract URL: Click here to view abstract

29. Topotecan in combination with cisplatin for the treatment of stage IVB, recurrent, or persistent cervical cancer.

Author: Brave M; Dagher R; Farrell A; Abraham S; Ramchandani R; Gobburu J; Booth B; Jiang X; Sridhara R; Justice R; Pazdur R;
Institution: Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. michael.brave@fda.hhs.gov
Journal: Oncology (Williston Park). 2006 Oct;20(11):1401-4, 1410; discussion 1410-11, 1415-6.
Abstract URL: Click here to view abstract

30. AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomised trial.

Author: Dobrowsky W; Huigol NG; Jayatilake RS; Kizilbash NI; Okkan S; Kagiya VT; Tatsuzaki H;
Institution: Northern Centre for Cancer Treatment, Newcastle General Hospital, Newcastle upon Tyne, UK. werner.dobrowsky@nuth.nhs.uk
Journal: Radiother Oncol. 2007 Jan;82(1):24-9. Epub 2006 Dec 11.
Abstract URL: Click here to view abstract

31. Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study.

Author: Mitchell DG; Snyder B; Coakley F; Reinhold C; Thomas G; Amendola M; Schwartz LH; Woodward P; Pannu H; Hricak H;
Institution: Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA. donald.mitchell@jefferson.edu
Journal: J Clin Oncol. 2006 Dec 20;24(36):5687-94.
Abstract URL: Click here to view abstract

32. Sentinel lymph node biopsy improves staging in early cervical cancer.

Author: Bats AS; Clement D; Larousserie F; Lefrere-Belda MA; Faraggi M; Froissart M; Lecuru F;
Institution: Service de Chirurgie Gynecologique, Hopital Europeen Georges Pompidou, 20 rue Leblanc 75015 Paris, France.
Journal: Gynecol Oncol. 2007 Apr;105(1):189-93. Epub 2007 Jan 12.
Abstract URL: Click here to view abstract

33. Effect of intravenously administered iron sucrose on the prevention of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy.

Author: Kim YT; Kim SW; Yoon BS; Cho HJ; Nahm EJ; Kim SH; Kim JH; Kim JW;
Institution: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei University College of Medicine, CPO Box 8044, Seoul 120-752, South Korea. ytkchoi@yumc.yonsei.ac.kr
Journal: Gynecol Oncol. 2007 Apr;105(1):199-204. Epub 2007 Jan 17.
Abstract URL: Click here to view abstract

34. The impact of age in the outcome of patients with advanced or recurrent cervical cancer after platinum-based chemotherapy.

Author: Kastritis E; Bamias A; Bozas G; Koutsoukou V; Voulgaris Z; Vlahos G; Rodolakis A; Gika D; Papadimitriou C; Dimopoulos MA;
Institution: University of Athens, Department of Clinical Therapeutics, Alexandra Hospital, 31 Komninon St, Haidari, 124 62, Athens, Greece.
Journal: Gynecol Oncol. 2007 Feb;104(2):372-6. Epub 2006 Oct 9.
Abstract URL: Click here to view abstract

35. A randomized phase III trial of concurrent chemoradiotherapy in locally advanced cervical cancer: preliminary results.

Author: Veerasarn V; Lorvidhaya V; Kamnerdsupaphon P; Suntornpong N; Sangruchi S; Lertsanguansinchai P; Khorprasert C; Sookpreedee L; Udompunturak S;
Institution: Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkoknoi, Bangkok, 10700, Thailand. vutisiri@hotmail.com
Journal: Gynecol Oncol. 2007 Jan;104(1):15-23. Epub 2006 Sep 25.
Abstract URL: Click here to view abstract

36. Radiation therapy with concomitant and adjuvant cisplatin and paclitaxel in high-risk cervical cancer: long-term follow-up.

Author: Argenta PA; Ghebre R; Dusenbery KE; Chen MD; Judson PL; Downs LS Jr; Carson LF;
Institution: Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, MN, USA.
Journal: Eur J Gynaecol Oncol. 2006;27(3):231-5.
Abstract URL: Click here to view abstract

37. An observational longitudinal study to evaluate miction, defecation, and sexual function after radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer.

Author: Pieterse QD; Maas CP; ter Kuile MM; Lowik M; van Eijkeren MA; Trimbos JB; Kenter GG;
Institution: Department of Gynaecology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. q.d.pieterse@lumc.nl
Journal: Int J Gynecol Cancer. 2006 May-Jun;16(3):1119-29.
Abstract URL: Click here to view abstract

38. Phase II study of tirapazamine plus cisplatin in patients with advanced or recurrent cervical cancer.

Author: Maluf FC; Leiser AL; Aghajanian C; Sabbatini P; Pezzulli S; Chi DS; Wolf JK; Levenback C; Loh E; Spriggs DR;
Institution: Developmental Chemotherapy Service and Gynecologic Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Journal: Int J Gynecol Cancer. 2006 May-Jun;16(3):1165-71.
Abstract URL: Click here to view abstract

39. Pemetrexed (Alimta, LY231514) demonstrates clinical activity in chemonaive patients with cervical cancer in a phase II single-agent trial.

Author: Goedhals L; van Wiyk AL; Smith BL; Fourie SJ;
Institution: Department of Oncotherapy, National Hospital, Private Bay, Bloemfontein X20598, South Africa. goedhall@doh.ofs.gov.za
Journal: Int J Gynecol Cancer. 2006 May-Jun;16(3):1172-8.
Abstract URL: Click here to view abstract

40. Randomized phase II study of immunomodulator Z-100 in patients with stage IIIB cervical cancer with radiation therapy.

Author: Noda K; Ohashi Y; Okada H; Ogita S; Ozaki M; Kikuchi Y; Takegawa Y; Niibe H; Fujii S; Horiuchi J; Morita K; Hashimoto S; Fujiwara K;
Institution: Kinki University, Japan.
Journal: Jpn J Clin Oncol. 2006 Sep;36(9):570-7. Epub 2006 Aug 22.
Abstract URL: Click here to view abstract

41. The European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life questionnaire cervical cancer module: EORTC QLQ-CX24.

Author: Greimel ER; Kuljanic Vlasic K; Waldenstrom AC; Duric VM; Jensen PT; Singer S; Chie W; Nordin A; Bjelic Radisic V; Wydra D;
Institution: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria. elfriede.greimel@meduni-graz.at
Journal: Cancer. 2006 Oct 15;107(8):1812-22.
Abstract URL: Click here to view abstract