Monday, December 1, 2008 - 9:20PM EST

Clinical Trials

1. Cetuximab for the treatment of colorectal cancer.

Author
Jonker DJ; O'Callaghan CJ; Karapetis CS; Zalcberg JR; Tu D; Au HJ; Berry SR; Krahn M; Price T; Simes RJ; Tebbutt NC; van Hazel G; Wierzbicki R; Langer C; Moore MJ;
Institution
Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. djonker@ottawahospital.on.ca
Journal
N Engl J Med. 2007 Nov 15;357(20):2040-8.
Abstract URL
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2. A randomized phase II trial evaluating safety and efficacy of an experimental chemotherapy regimen (irinotecan + oxaliplatin, IRINOX) and two standard arms (LV5 FU2 + irinotecan or LV5 FU2 + oxaliplatin) in first-line metastatic colorectal cancer: a study of the Digestive Group of the Federation Nationale des Centres de Lutte Contre le Cancer.

Author
Becouarn Y; Senesse P; Thezenas S; Boucher E; Adenis A; Cany L; Jacob JH; Cvitkovic F; Montoto-Grillot C; Ychou M;
Institution
Department of Digestive Oncology, Institut Bergonie, Regional Cancer Center, Bordeaux, France. becouarn@bergonie.org
Journal
Ann Oncol. 2007 Dec;18(12):2000-5. Epub 2007 Sep 4.
Abstract URL
Click here to view abstract

3. An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy.

Author
Van Cutsem E; Siena S; Humblet Y; Canon JL; Maurel J; Bajetta E; Neyns B; Kotasek D; Santoro A; Scheithauer W; Spadafora S; Amado RG; Hogan N; Peeters M;
Institution
Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium.
Journal
Ann Oncol. 2008 Jan;19(1):92-8. Epub 2007 Sep 4.
Abstract URL
Click here to view abstract

4. A randomized multicenter trial to compare long-term functional outcome, quality of life, and complications of surgical procedures for low rectal cancers.

Author
Fazio VW; Zutshi M; Remzi FH; Parc Y; Ruppert R; Furst A; Celebrezze J Jr; Galanduik S; Orangio G; Hyman N; Bokey L; Tiret E; Kirchdorfer B; Medich D; Tietze M; Hull T; Hammel J;
Institution
Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Journal
Ann Surg. 2007 Sep;246(3):481-8; discussion 488-90.
Abstract URL
Click here to view abstract

5. Five-year colon surveillance after screening colonoscopy.

Author
Lieberman DA; Weiss DG; Harford WV; Ahnen DJ; Provenzale D; Sontag SJ; Schnell TG; Chejfec G; Campbell DR; Kidao J; Bond JH; Nelson DB; Triadafilopoulos G; Ramirez FC; Collins JF; Johnston TK; McQuaid KR; Garewal H; Sampliner RE; Esquivel R; Robertson D;
Institution
Department of Veterans Affairs Medical Center, Portland, Oregon 97239, USA. lieberma@ohsu.edu
Journal
Gastroenterology. 2007 Oct;133(4):1077-85.
Abstract URL
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6. Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741.

Author
Dy GK; Krook JE; Green EM; Sargent DJ; Delaunoit T; Morton RF; Fuchs CS; Ramanathan RK; Williamson SK; Findlay BP; Pockaj BA; Sticca RP; Alberts SR; Pitot HC 4th; Goldberg RM;
Institution
Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. dy.grace@mayo.edu
Journal
J Clin Oncol. 2007 Aug 10;25(23):3469-74.
Abstract URL
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7. Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer.

Author
Hecht JR; Patnaik A; Berlin J; Venook A; Malik I; Tchekmedyian S; Navale L; Amado RG; Meropol NJ;
Institution
University of California School of Medicine, Los Angeles, CA, USA.
Journal
Cancer. 2007 Sep 1;110(5):980-8.
Abstract URL
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8. A Phase II safety and effect on time to tumor progression study of intratumoral light infusion technology using talaporfin sodium in patients with metastatic colorectal cancer.

Author
Kujundzic M; Vogl TJ; Stimac D; Rustemovic N; Hsi RA; Roh M; Katicic M; Cuenca R; Lustig RA; Wang S;
Institution
Department of Medicine, Division of Gastroenterology, University Hospital Dubrava, Zagreb, Croatia.
Journal
J Surg Oncol. 2007 Nov 1;96(6):518-24.
Abstract URL
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9. Capecitabine plus oxaliplatin and irinotecan regimen every other week: a phase I/II study in first-line treatment of metastatic colorectal cancer.

Author
Bajetta E; Celio L; Ferrario E; Di Bartolomeo M; Denaro A; Dotti K; Mancin M; Bajetta R; Colombo A; Pusceddu S;
Institution
Medical Oncology Unit 2, Fondazione IRCCS 'Istituto Nazionale Tumori', Milan, Italy. emilio.bajetta@istitutotumori.mi.it
Journal
Ann Oncol. 2007 Nov;18(11):1810-6. Epub 2007 Sep 6.
Abstract URL
Click here to view abstract

10. Colonoscopic screening of first-degree relatives of patients with large adenomas: increased risk of colorectal tumors.

Author
Cottet V; Pariente A; Nalet B; Lafon J; Milan C; Olschwang S; Bonaiti-Pellie C; Faivre J; Bonithon-Kopp C;
Institution
INSERM Unite 866, Dijon, France.
Journal
Gastroenterology. 2007 Oct;133(4):1086-92. Epub 2007 Jul 25.
Abstract URL
Click here to view abstract
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