Friday, November 20, 2009 - 5:08PM EST

Treatment of Stable Chronic Obstructive Pulmonary Disease (COPD)

Management of Chronic Bronchitis

Chronic bronchitis is an inflammation of the bronchi that is characterized by cough and expectoration of sputum that occurs on most days for at least 3 months. In order to qualify for a diagnosis of chronic bronchitis, all other lung and/or heart conditions that can cause similar symptoms (e.g., cough; sputum production) must be excluded as the cause. Approximately 85% to 90% of cases of chronic bronchitis are caused by cigarette smoking and the rest of the cases are caused by occupational and/or environmental exposure to a variety of irritants (e.g., organic dusts; chemicals; agricultural products; air pollutants).

Principles of management of people with chronic bronchitis includes:

  • Smoking cessation - 90% of patients will experience resolution of cough and sputum production after quitting smoking

  • Avoidance of exposure to occupational and environmental irritants

  • Antibiotics

    • not recommended for routine use in patients with stable chronic bronchitis
    • usually reserved for acute exacerbations of chronic bronchitis
  • Inhaled bronchodilators

    • in patients with stable chronic bronchits, short-acting Beta agonist inhaled bronchodilators (e.g., albuterol) have been shown to improve lung function, shortness of breath, and exercise toerance.
    • in patients with stable chronic bronchitis, a short-acting anticholinergic bronchodilator (e.g., ipratroprium) can be used to control coughing
    • short-acting Beta agonists and short-acting anticholinertic inhaled bronchodilators are also recommended for the treatment of acute exacerbations of acute exacerbations of chronic bronchitis
  • Corticosteroids

    • inhaled corticosteroids, in combination with a long-acting Beta agonist bronchodilator, are recommended to control coughing in patients with stable chronic bronchitis
    • a short-course of systemic or oral corticosteroids (10-15 days) is recommended to improve cough in patients with acute exacerbations
  • Expectorants

    • expectorants are substances that help to loosen and clear mucous and phlegm from the respiratory tract
    • expectorants are not recommended for the treatment of cough in patients with either stable or acute exacerbations of chronic bronchitis since evidence of efficacy is lacking
  • Antitussive agents

    • antitussive agents are medications that help to suppress cough by acting on the medullary cough center in the brain
    • antitussive agents, such as codeine and dextromethorphan, may be used for temporary cough suppression in patients with chronic bronchitis