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Clinical Trials

1. Adjunctive topiramate treatment in refractory obese bipolar patients: a descriptive open label study.

Author: Gabriel A;
Institution: University of Calgary, Calgary, Alberta, Canada. gabriel@ucalgary.ca
Journal: Eat Weight Disord. 2007 Mar;12(1):48-53.
Abstract URL: Click here to view abstract

2. Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials.

Author: Calabrese JR; Huffman RF; White RL; Edwards S; Thompson TR; Ascher JA; Monaghan ET; Leadbetter RA;
Institution: Case Western Reserve University School of Medicine/University Hospitals of Cleveland, Cleveland, OH, USA. joseph.calabrese@uhhospitals.org
Journal: Bipolar Disord. 2008 Mar;10(2):323-33.
Abstract URL: Click here to view abstract

3. Olanzapine or lamotrigine addition to lithium in remitted bipolar disorder patients with anxiety disorder comorbidity: a randomized, single-blind, pilot study.

Author: Maina G; Albert U; Rosso G; Bogetto F;
Institution: Department of Neurosciences, Mood and Anxiety Disorders Unit, University of Turin, Turin, Italy. giuseppemaina@hotmail.com
Journal: J Clin Psychiatry. 2008 Apr;69(4):609-16.
Abstract URL: Click here to view abstract

4. Efficacy and safety of aripiprazole in subpopulations with acute manic or mixed episodes of bipolar I disorder.

Author: Suppes T; Eudicone J; McQuade R; Pikalov A 3rd; Carlson B;
Institution: Bipolar Disorder Research Program, UT Southwestern Medical Center, Dallas, Texas 75390-9121, USA. trisha.suppes@utsouthwestern.edu
Journal: J Affect Disord. 2008 Apr;107(1-3):145-54. Epub 2007 Sep 27.
Abstract URL: Click here to view abstract

5. Mindfulness-based Cognitive Therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning.

Author: Williams JM; Alatiq Y; Crane C; Barnhofer T; Fennell MJ; Duggan DS; Hepburn S; Goodwin GM;
Institution: University of Oxford, Department of Psychiatry, Warneford Hospital, Warneford Lane, Headington, Oxford, OX3 7JX, UK. mark.williams@psych.ox.ac.uk
Journal: J Affect Disord. 2008 Apr;107(1-3):275-9. Epub 2007 Sep 19.
Abstract URL: Click here to view abstract

6. The effects of pentazocine, a kappa agonist, in patients with mania.

Author: Cohen BM; Murphy B;
Institution: McLean Hospital, Belmont, MA 02478, USA. cohenb@mclean.harvard.edu
Journal: Int J Neuropsychopharmacol. 2008 Mar;11(2):243-7. Epub 2007 Sep 26.
Abstract URL: Click here to view abstract

7. Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: a randomized, double-blind, placebo-controlled study.

Author: Vieta E; Calabrese JR; Goikolea JM; Raines S; Macfadden W;
Institution: Bipolar Disorders Programme, Clinical Institute of Neuroscience, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. evieta@clinic.ub.es
Journal: Bipolar Disord. 2007 Jun;9(4):413-25.
Abstract URL: Click here to view abstract

8. A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania.

Author: Yatham LN; Vieta E; Young AH; Moller HJ; Paulsson B; Vagero M;
Institution: Division of Mood Disorders, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada. yatham@interchange.ubc.ca
Journal: Int Clin Psychopharmacol. 2007 Jul;22(4):212-20.
Abstract URL: Click here to view abstract

9. Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study.

Author: Nery FG; Monkul ES; Hatch JP; Fonseca M; Zunta-Soares GB; Frey BN; Bowden CL; Soares JC; Nery FG; Monkul ES; Hatch JP; Fonseca M; Zunta-Soares GB; Frey BN; Bowden CL; Soares JC;
Institution: Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Journal: Hum Psychopharmacol. 2008 Mar;23(2):87-94.
Abstract URL: Click here to view abstract

10. Response and remission rates in Chinese patients with bipolar mania treated for 4 weeks with either quetiapine or lithium: a randomized and double-blind study.

Author: Li H; Ma C; Wang G; Zhu X; Peng M; Gu N;
Institution: Shanghai Mental Health Center, Shanghai, China.
Journal: Curr Med Res Opin. 2008 Jan;24(1):1-10.
Abstract URL: Click here to view abstract

11. A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression.

Author: Frye MA; Grunze H; Suppes T; McElroy SL; Keck PE Jr; Walden J; Leverich GS; Altshuler LL; Nakelsky S; Hwang S; Mintz J; Post RM;
Institution: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA. mfrye@mayo.edu
Journal: Am J Psychiatry. 2007 Aug;164(8):1242-9.
Abstract URL: Click here to view abstract

12. Comparison of short-term venlafaxine versus lithium monotherapy for bipolar II major depressive episode: a randomized open-label study.

Author: Amsterdam JD; Shults J;
Institution: Department of Psychiatry, Depression Research Unit, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-3309, USA. jamsterd@mail.med.upenn.edu
Journal: J Clin Psychopharmacol. 2008 Apr;28(2):171-81.
Abstract URL: Click here to view abstract

13. Cognitive functioning and acute sedative effects of risperidone and quetiapine in patients with stable bipolar I disorder: a randomized, double-blind, crossover study.

Author: Harvey PD; Hassman H; Mao L; Gharabawi GM; Mahmoud RA; Engelhart LM;
Institution: Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA.
Journal: J Clin Psychiatry. 2007 Aug;68(8):1186-94.
Abstract URL: Click here to view abstract

14. Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder.

Author: Goldberg JF; Bowden CL; Calabrese JR; Ketter TA; Dann RS; Frye MA; Suppes T; Post RM;
Institution: Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA. JFGoldberg@yahoo.com
Journal: Biol Psychiatry. 2008 Jan 1;63(1):125-30. Epub 2007 Jun 1.
Abstract URL: Click here to view abstract

15. Effectiveness of adjunctive antidepressant treatment for bipolar depression.

Author: Sachs GS; Nierenberg AA; Calabrese JR; Marangell LB; Wisniewski SR; Gyulai L; Friedman ES; Bowden CL; Fossey MD; Ostacher MJ; Ketter TA; Patel J; Hauser P; Rapport D; Martinez JM; Allen MH; Miklowitz DJ; Otto MW; Dennehy EB; Thase ME;
Institution: Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. gsachs@partners.org
Journal: N Engl J Med. 2007 Apr 26;356(17):1711-22. Epub 2007 Mar 28.
Abstract URL: Click here to view abstract

16. Effects of adjunctive antidepressant therapy with quetiapine on clinical outcome, quality of sleep and daytime motor activity in patients with treatment-resistant depression.

Author: Baune BT; Caliskan S; Todder D;
Institution: Department of Psychiatry, James Cook University, Townsville, Australia. Bernhard.Baune@jcu.edu.au
Journal: Hum Psychopharmacol. 2007 Jan;22(1):1-9.
Abstract URL: Click here to view abstract

17. Lower weight gain with the orally disintegrating olanzapine than with standard tablets in first-episode never treated psychotic patients.

Author: Arranz B; San L; Duenas RM; Centeno M; Ramirez N; Salavert J; Del Moral E;
Institution: Hospital San Rafael, Barcelona, Spain.
Journal: Hum Psychopharmacol. 2007 Jan;22(1):11-5.
Abstract URL: Click here to view abstract

18. Association between illicit drug and alcohol use and first manic episode.

Author: Frank E; Boland E; Novick DM; Bizzarri JV; Rucci P;
Institution: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. franke@msx.upmc.edu
Journal: Pharmacol Biochem Behav. 2007 Feb;86(2):395-400. Epub 2006 Dec 26.
Abstract URL: Click here to view abstract

19. A sham-controlled trial of the efficacy and safety of twice-daily rTMS in major depression.

Author: Loo CK; Mitchell PB; McFarquhar TF; Malhi GS; Sachdev PS;
Institution: School of Psychiatry, University of NSW and Black Dog Institute, Sydney, Australia. colleen.loo@unsw.edu.au
Journal: Psychol Med. 2007 Mar;37(3):341-9. Epub 2006 Dec 19.
Abstract URL: Click here to view abstract

20. A randomized, double-blind, placebo-controlled study of quetiapine in the treatment of bipolar I and II depression: improvements in quality of life.

Author: Endicott J; Rajagopalan K; Minkwitz M; Macfadden W;
Institution: New York State Psychiatric Institute, New York City, NY 10032, USA. je10@columbia.edu
Journal: Int Clin Psychopharmacol. 2007 Jan;22(1):29-37.
Abstract URL: Click here to view abstract

21. Health-related quality of life in euthymic bipolar disorder patients: differences between bipolar I and II subtypes.

Author: Maina G; Albert U; Bellodi L; Colombo C; Faravelli C; Monteleone P; Bogetto F; Cassano GB; Maj M;
Institution: Department of Neurosciences, Mood and Anxiety Disorders Unit, University of Turin, Italy. giuseppemaina@hotmail.com
Journal: J Clin Psychiatry. 2007 Feb;68(2):207-12.
Abstract URL: Click here to view abstract

22. Number needed to treat and time to response/remission for quetiapine monotherapy efficacy in acute bipolar depression: evidence from a large, randomized, placebo-controlled study.

Author: Cookson J; Keck PE Jr; Ketter TA; Macfadden W;
Institution: The Department of Psychiatry, Royal London Hospital, London, UK. john.cookson@elcmht.nhs.uk
Journal: Int Clin Psychopharmacol. 2007 Mar;22(2):93-100.
Abstract URL: Click here to view abstract

23. A 2-year, open-label pilot study of adjunctive chromium in patients with treatment-resistant rapid-cycling bipolar disorder.

Author: Amann BL; Mergl R; Vieta E; Born C; Hermisson I; Seemueller F; Dittmann S; Grunze H;
Institution
Journal: J Clin Psychopharmacol. 2007 Feb;27(1):104-6.

24. A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence.

Author: Weiss RD; Griffin ML; Kolodziej ME; Greenfield SF; Najavits LM; Daley DC; Doreau HR; Hennen JA;
Institution: Department of Psychiatry, Harvard Medical School, Boston, and McLean Hospital, 115 Mill St., Belmont, MA 02478, USA. rweiss@mclean.harvard.edu
Journal: Am J Psychiatry. 2007 Jan;164(1):100-7.
Abstract URL: Click here to view abstract