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New Developments
Researchers studied the impact of progressive strength training and aerobic exercise on the cardiovascular fitness of fibromyalgic women. Improvement was noted in muscle strength, cardiovascular function and general functional status as well as a possible reduction in the severity of certain symptoms. The study appears in Arthritis and Rheumatism Vol. 47(1):22-8, February, 2002.
24 female patients with fibromyalgia participated in a study to determine the efficacy of osteopathic manipulative treatment (OMT) in conjunction with standard medical care. Based on a questionnaire, results indicated that the response to OMT with medication was more efficacious than medical care alone. The study appears in Journal of the American Osteopathic Association Vol. 102(6):321-5, June 2002.
Researchers in Brazil investigated the use of acupuncture as a treatment for fibromyalgia. Following traditional acupuncture, a questionnaire filled out by the participants indicated an increased quality of life. The study appears in Current Pain and Headache Reports Vol. 6(5):379-83, October 2002.
In a systematic review of nonpharmacological treatments for fibromyalgia, reviewers found that there was no strong support for any particular intervention, though there was slightly more evidence favoring aerobic exercise. The review appears in Clinical Journal of Pain Vol. 18(5):324-36, September-October 2002.
Research is focusing on several aspects of fibromyalgia:
Neurohormonal and biochemical abnormalities, including Substance P (an inflammatory mediator involved in pain and inflammation).
Possible relationship between viral illness and immune abnormalities.
The relationship between trauma and the development of fibromyalgia.
The relationship between fibromyalgia, depression, and irritable bowel syndrome.
The possible role of faulty regulation by thyroid hormone in people with fibromyalgia.
The role of cortisol, a hormone produced by the adrenal glands, in fibromyalgia.
The role of psychological stress in the development of fibromyalgia.
The role of genetics in the development of fibromyalgia.
Researchers have observed in fibromyalgia patients the activation of N-methyl-D-aspartate (NMDA) receptors, which interact with excitatory amino acids and increase chronic (but not acute) pain.
Several randomized, controlled clinical trials have demonstrated that tropisetron, a 5-HT3 receptor agonist, is effective for the treatment of symptoms associated with fibromyalgia syndrome.
Researchers recently reported that electroconvulsive therapy improved severe pain in people with fibromyalgia.
Researchers recently reported that exercise in waist-high warm water decreased pain and improved health-related quality of life in women with fibromyalgia.
Hyperbaric oxygen therapy is being investigated as a novel and potentially effective treatment for fibromyalgia.
Information regarding ongoing clinical studies in your area can be obtained at the Clinical Trials Listing Service at http://www.centerwatch.com
