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Fibromyalgia > What Your Doctor is Reading About Fibromyalgia > Clinical Trials

Clinical Trials

1. Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen.

Author: Bennett RM; Schein J; Kosinski MR; Hewitt DJ; Jordan DM; Rosenthal NR;
Institution: Oregon Health and Science University, Portland, OR 97239, USA. bennetro@ohsu.edu
Journal: Arthritis Rheum. 2005 Aug 15;53(4):519-27.
Abstract URL: Click here to view abstract

2. Efficacy of cognitive-behavioral intervention for juvenile primary fibromyalgia syndrome.

Author: Kashikar-Zuck S; Swain NF; Jones BA; Graham TB;
Institution: Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA. Susmita.Kashikar-Zuck@cchmc.org
Journal: J Rheumatol. 2005 Aug;32(8):1594-602.
Abstract URL: Click here to view abstract

3. A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications.

Author: Holman AJ; Myers RR;
Institution: Pacific Rheumatology Associates, Renton, Washington 98055, USA. ajhseattle@aol.com
Journal: Arthritis Rheum. 2005 Aug;52(8):2495-505.
Abstract URL: Click here to view abstract

4. A randomized clinical trial of an individualized home-based exercise programme for women with fibromyalgia.

Author: Da Costa D; Abrahamowicz M; Lowensteyn I; Bernatsky S; Dritsa M; Fitzcharles MA; Dobkin PL;
Institution: Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, H3G 1A4 Canada. Deborah.DaCosta@mcgill.ca
Journal: Rheumatology (Oxford). 2005 Nov;44(11):1422-7. Epub 2005 Jul 19.
Abstract URL: Click here to view abstract

5. A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia.

Author: Finckh A; Berner IC; Aubry-Rozier B; So AK;
Institution: Rheumatology Department, University Hospital of Vaud (CHUV), Lausanne, Switzerland. afinckh@post.harvard.edu
Journal: J Rheumatol. 2005 Jul;32(7):1336-40.
Abstract URL: Click here to view abstract

6. Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial.

Author: Edinger JD; Wohlgemuth WK; Krystal AD; Rice JR; Edinger JD; Wohlgemuth WK; Krystal AD; Rice JR;
Institution: Psychology Service, Veterans Affairs Medical Center, Durham, NC 27705, USA. jack.edinger@duke.edu
Journal: Arch Intern Med. 2005 Nov 28;165(21):2527-35.
Abstract URL: Click here to view abstract

7. A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder.

Author: Arnold LM; Rosen A; Pritchett YL; D'Souza DN; Goldstein DJ; Iyengar S; Wernicke JF;
Institution: Women's Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA. lesley.arnold@uc.edu
Journal: Pain. 2005 Dec 15;119(1-3):5-15. Epub 2005 Nov 17.
Abstract URL: Click here to view abstract

8. Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.

Author: Ozerbil O; Okudan N; Gokbel H; Levendoglu F;
Institution: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Selcuk University, Meram, Konya, Turkey. ozerbil@yahoo.com
Journal: Clin Rheumatol. 2006 Jul;25(4):495-7. Epub 2005 Nov 3.
Abstract URL: Click here to view abstract

9. Characterization and consequences of pain variability in individuals with fibromyalgia.

Author: Harris RE; Williams DA; McLean SA; Sen A; Hufford M; Gendreau RM; Gracely RH; Clauw DJ;
Institution: Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA. reharris@med.umich.edu
Journal: Arthritis Rheum. 2005 Nov;52(11):3670-4.
Abstract URL: Click here to view abstract

10. A pilot study of the effects of behavioral weight loss treatment on fibromyalgia symptoms.

Author: Shapiro JR; Anderson DA; Danoff-Burg S;
Institution: Department of Psychology, University at Albany, State University of New York, Albany, NY, USA.
Journal: J Psychosom Res. 2005 Nov;59(5):275-82.
Abstract URL: Click here to view abstract

11. Open trial of pindolol in the treatment of fibromyalgia.

Author: Wood PB; Kablinger AS; Caldito GS;
Institution: Department of Family Medicine, Louisiana State University Health Science Center-Shreveport, LA 71103-3932, USA. pwood@lsuhsc.edu
Journal: Ann Pharmacother. 2005 Nov;39(11):1812-6. Epub 2005 Oct 11.
Abstract URL: Click here to view abstract

12. Efficacy of milnacipran in patients with fibromyalgia.

Author: Gendreau RM; Thorn MD; Gendreau JF; Kranzler JD; Ribeiro S; Gracely RH; Williams DA; Mease PJ; McLean SA; Clauw DJ;
Institution: Cypress Biosciences, 4350 Executive Drive, San Diego, CA 92121, USA. mgendreau1@cypressbio.com
Journal: J Rheumatol. 2005 Oct;32(10):1975-85.
Abstract URL: Click here to view abstract

13. The effects of a 12-week strength-training program on strength and functionality in women with fibromyalgia.

Author: Kingsley JD; Panton LB; Toole T; Sirithienthad P; Mathis R; McMillan V;
Institution: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
Journal: Arch Phys Med Rehabil. 2005 Sep;86(9):1713-21.
Abstract URL: Click here to view abstract

14. Aquatic training and detraining on fitness and quality of life in fibromyalgia.

Author: Tomas-Carus P; Hakkinen A; Gusi N; Leal A; Hakkinen K; Ortega-Alonso A;
Institution: Fitness and Lifequality Laboratory, Faculty of Sports Sciences, University of Extremadura, Caceres, Spain.
Journal: Med Sci Sports Exerc. 2007 Jul;39(7):1044-50.
Abstract URL: Click here to view abstract

15. Effects of yoga and the addition of Tui Na in patients with fibromyalgia.

Author: da Silva GD; Lorenzi-Filho G; Lage LV;
Institution: Pulmonary Division, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil. ge.daddio@ig.com.br
Journal: J Altern Complement Med. 2007 Dec;13(10):1107-13.
Abstract URL: Click here to view abstract

16. Effects of topical essential oil on exercise volume after a 12-week exercise program for women with fibromyalgia: a pilot study.

Author: Rutledge DN; Jones CJ;
Institution: Department of Nursing, California State University, Fullerton, CA 92834-6868, USA. drutledge@fullerton.edu
Journal: J Altern Complement Med. 2007 Dec;13(10):1099-106.
Abstract URL: Click here to view abstract

17. A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain.

Author: Thomas AW; Graham K; Prato FS; McKay J; Forster PM; Moulin DE; Chari S;
Institution: Bioelectromagnetics, Imaging Program, Lawson Health Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada. athomas@lawsonimaging.ca
Journal: Pain Res Manag. 2007 Winter;12(4):249-58.
Abstract URL: Click here to view abstract

18. Growth hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels. A pilot study.

Author: Cuatrecasas G; Riudavets C; Guell MA; Nadal A;
Institution: Servicio de Endocrinologia y Nutricion, Centro Medico Teknon, Vilana 12, E-08022 Barcelona, Spain. endocrinologia@teknon.es
Journal: BMC Musculoskelet Disord. 2007 Nov 30;8:119.
Abstract URL: Click here to view abstract

19. The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia.

Author: Arnold LM; Crofford LJ; Martin SA; Young JP; Sharma U;
Institution: Women's Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Lesley.Arnold@uc.edu
Journal: Pain Med. 2007 Nov-Dec;8(8):633-8.
Abstract URL: Click here to view abstract

20. Group exercise, education, and combination self-management in women with fibromyalgia: a randomized trial.

Author: Rooks DS; Gautam S; Romeling M; Cross ML; Stratigakis D; Evans B; Goldenberg DL; Iversen MD; Katz JN;
Institution: Novartis Institutes for Biomedical Research, Inc, Translational Medicine, 400 Technology Square, Cambridge, MA 02139, USA. daniel.rooks@novartis.com
Journal: Arch Intern Med. 2007 Nov 12;167(20):2192-200.
Abstract URL: Click here to view abstract

21. Effectiveness of muscle stretching exercises with and without laser therapy at tender points for patients with fibromyalgia.

Author: Matsutani LA; Marques AP; Ferreira EA; Assumpcao A; Lage LV; Casarotto RA; Pereira CA;
Institution: Department of Health and Biological Sciences, FIEO University, Osasco, Brazil. lukemi@ig.com.br
Journal: Clin Exp Rheumatol. 2007 May-Jun;25(3):410-5.
Abstract URL: Click here to view abstract

22. The effectiveness of multidisciplinary rehabilitation in the treatment of fibromyalgia: a randomized controlled trial.

Author: Lemstra M; Olszynski WP;
Institution: College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Journal: Clin J Pain. 2005 Mar-Apr;21(2):166-74.
Abstract URL: Click here to view abstract

23. Spa treatment for primary fibromyalgia syndrome: a combination of thalassotherapy, exercise and patient education improves symptoms and quality of life.

Author: Zijlstra TR; van de Laar MA; Bernelot Moens HJ; Taal E; Zakraoui L; Rasker JJ;
Institution: Department of Rheumatology, Medisch Spectrum Twente Hospital, Enschede, The Netherlands. t.r.zijlstra@worldonline.nl
Journal: Rheumatology (Oxford). 2005 Apr;44(4):539-46. Epub 2005 Feb 3.
Abstract URL: Click here to view abstract

24. Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: a randomized, sham-controlled study.

Author: Roizenblatt S; Fregni F; Gimenez R; Wetzel T; Rigonatti SP; Tufik S; Boggio PS; Valle AC;
Institution: Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Journal: Pain Pract. 2007 Dec;7(4):297-306. Epub 2007 Nov 6.
Abstract URL: Click here to view abstract

25. Effects of mud-bath treatment on fibromyalgia patients: a randomized clinical trial.

Author: Fioravanti A; Perpignano G; Tirri G; Cardinale G; Gianniti C; Lanza CE; Loi A; Tirri E; Sfriso P; Cozzi F;
Institution: Rheumatology Unit, Department of Clinical Medicine and Immunogical Sciences, University of Siena, Siena, Italy.
Journal: Rheumatol Int. 2007 May 23;.
Abstract URL: Click here to view abstract

26. Evaluation of psychophysiological asymmetry in patients with fibromyalgia syndrome.

Author: Mitani Y; Fukunaga M; Kanbara K; Takebayashi N; Ishino S; Nakai Y;
Institution: Department of Psychosomatic Medicine, Kansai Medical University, Moriguchi-shi, Osaka, Japan. mitaniy@takii.kmu.ac.jp
Journal: Appl Psychophysiol Biofeedback. 2006 Sep;31(3):217-25. Epub 2006 Aug 3.
Abstract URL: Click here to view abstract

27. Psychiatric comorbidities in a community sample of women with fibromyalgia.

Author: Raphael KG; Janal MN; Nayak S; Schwartz JE; Gallagher RM;
Institution: University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Psychiatry, Newark, NJ 07103, USA. raphaekg@umdnj.edu
Journal: Pain. 2006 Sep;124(1-2):117-25. Epub 2006 May 15.
Abstract URL: Click here to view abstract

28. Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients.

Author: Rossini M; Di Munno O; Valentini G; Bianchi G; Biasi G; Cacace E; Malesci D; La Montagna G; Viapiana O; Adami S; Rossini M; Di Munno O; Valentini G; Bianchi G; Biasi G; Cacace E; Malesci D; La Montagna G; Viapiana O; Adami S;
Institution: Rheumatology Unit, University of Verona, Italy.
Journal: Clin Exp Rheumatol. 2007 Mar-Apr;25(2):182-8.
Abstract URL: Click here to view abstract

29. Reduction of fibromyalgia symptoms through intravenous nutrient therapy: results of a pilot clinical trial.

Author: Massey PB;
Institution: Complementary and Alternative Medicine at Alexian Brothers Hospital Network, Elk Grove Village, Ill, USA.
Journal: Altern Ther Health Med. 2007 May-Jun;13(3):32-4.
Abstract URL: Click here to view abstract

30. Hydrotherapy and conventional physiotherapy improve total sleep time and quality of life of fibromyalgia patients: randomized clinical trial.

Author: Vitorino DF; Carvalho LB; Prado GF;
Institution: UNILAVRAS, Lavras, MG, Brazil.
Journal: Sleep Med. 2006 Apr;7(3):293-6. Epub 2006 Mar 24.
Abstract URL: Click here to view abstract

31. Effectiveness of acupuncture in the treatment of fibromyalgia.

Author: Singh BB; Wu WS; Hwang SH; Khorsan R; Der-Martirosian C; Vinjamury SP; Wang CN; Lin SY;
Institution: Southern California University of Health Sciences, Whittier, USA.
Journal: Altern Ther Health Med. 2006 Mar-Apr;12(2):34-41.
Abstract URL: Click here to view abstract

32. Predictors of adherence to treatment in women with fibromyalgia.

Author: Dobkin PL; Sita A; Sewitch MJ;
Institution: Department of Medicine, McGill University, Montreal, Quebec, Canada. patricia.dobkin@mcgill.ca
Journal: Clin J Pain. 2006 Mar-Apr;22(3):286-94.
Abstract URL: Click here to view abstract

33. Electroconvulsive therapy improves severe pain associated with fibromyalgia.

Author: Usui C; Doi N; Nishioka M; Komatsu H; Yamamoto R; Ohkubo T; Ishizuka T; Shibata N; Hatta K; Miyazaki H; Nishioka K; Arai H;
Institution: Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan. chiec@med.juntendo.ac.jp
Journal: Pain. 2006 Apr;121(3):276-80. Epub 2006 Feb 21.
Abstract URL: Click here to view abstract

34. Effects of guided imagery on outcomes of pain, functional status, and self-efficacy in persons diagnosed with fibromyalgia.

Author: Menzies V; Taylor AG; Bourguignon C;
Institution: Florida International University, School of Nursing, Miami, FL 33199, USA. menzies@fiu.edu
Journal: J Altern Complement Med. 2006 Jan-Feb;12(1):23-30.
Abstract URL: Click here to view abstract

35. Exercise in waist-high warm water decreases pain and improves health-related quality of life and strength in the lower extremities in women with fibromyalgia.

Author: Gusi N; Tomas-Carus P; Hakkinen A; Hakkinen K; Ortega-Alonso A;
Institution: Fitness and Lifequality Laboratory, Sports Sciences Faculty, University of Extremadura, Avenue Universidad s/n, 10071 Caceres, Spain. ngusi@unex.es
Journal: Arthritis Rheum. 2006 Feb 15;55(1):66-73.
Abstract URL: Click here to view abstract

36. A randomized controlled trial of deep water running: clinical effectiveness of aquatic exercise to treat fibromyalgia.

Author: Assis MR; Silva LE; Alves AM; Pessanha AP; Valim V; Feldman D; Neto TL; Natour J;
Institution: Division of Rheumatology, Sao Paulo Federal University, Rua Botucatu 740, 04023-900 Sao Paulo, Brazil.
Journal: Arthritis Rheum. 2006 Feb 15;55(1):57-65.
Abstract URL: Click here to view abstract

37. Slow-frequency rTMS reduces fibromyalgia pain.

Author: Sampson SM; Rome JD; Rummans TA;
Institution: Department of Psychiatry and Psychology, W11A, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. sampson.shirlene@mayo.edu
Journal: Pain Med. 2006 Mar-Apr;7(2):115-8.
Abstract URL: Click here to view abstract

38. Sleep quality in patients with fibromyalgia using the Pittsburgh Sleep Quality Index.

Author: Osorio CD; Gallinaro AL; Lorenzi-Filho G; Lage LV; Osorio CD; Gallinaro AL; Lorenzi-Filho G; Lage LV;
Institution: Division of Rheumatology and the Sleep Laboratory, Heart Institute, Department of Internal Medicine, Hospital das Clinicas, Faculdade de Medicina, University of Sao Paulo, Brazil.
Journal: J Rheumatol. 2006 Sep;33(9):1863-5. Epub 2006 Aug 15.
Abstract URL: Click here to view abstract

39. Functionally oriented rehabilitation program for patients with fibromyalgia: preliminary results.

Author: Wennemer HK; Borg-Stein J; Gomba L; Delaney B; Rothmund A; Barlow D; Breeze G; Thompson A;
Institution: Spinal Cord Injury Unit, West Roxbury Division, VA Boston Health Care System, West Roxbury, Massachusetts 02132, USA.
Journal: Am J Phys Med Rehabil. 2006 Aug;85(8):659-66.
Abstract URL: Click here to view abstract

40. Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial.

Author: Martin DP; Sletten CD; Williams BA; Berger IH;
Institution: Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA. martin.david@mayo.edu
Journal: Mayo Clin Proc. 2006 Jun;81(6):749-57.
Abstract URL: Click here to view abstract

41. Exposure to a specific pulsed low-frequency magnetic field: a double-blind placebo-controlled study of effects on pain ratings in rheumatoid arthritis and fibromyalgia patients.

Author: Shupak NM; McKay JC; Nielson WR; Rollman GB; Prato FS; Thomas AW;
Institution: Lawson Health Research Institute, St. Joseph's Health Care, London, Ontario N6A 4V2.
Journal: Pain Res Manag. 2006 Summer;11(2):85-90.
Abstract URL: Click here to view abstract

42. The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients.

Author: Cohen SP; Verdolin MH; Chang AS; Kurihara C; Morlando BJ; Mao J;
Institution: Pain Management Division, Department of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA. scohen40@jhmi.edu
Journal: J Pain. 2006 Jun;7(6):391-8.
Abstract URL: Click here to view abstract