Wednesday, December 3, 2008 - 6:54PM EST

Introduction to Rheumatoid Arthritis

Risk Factors for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a relatively common condition affecting approximately 0.8% of the adult population worldwide. It is estimated that about 2.1 million people in the United States suffer from rheumatoid arthritis. Most people develop the disease between the ages of 30-50 and the disease affects women about 2-3 times more often than men. According to the American College of Rheumatology, RA acounts for about 9 million physician office visits and about 250,000 hospitalizations each year.

A risk factor is anything that increases the chances of a person developing a disease or condition. Risk factors for rheumatoid arthritis (RA) include:

  • Advancing Age - The risk for developing RA increases with age with most people being diagnosed in the 30-50 age group. The disease rarely occurs in men under 30 years of age.

  • Gender - The risk for developing RA is about 2-3 times higher for women than for men. For unknown reasons, pregnant women with RA generally experience an improvement in symptoms, however, the symptoms tend to recur shortly after childbirth.

  • Family history of RA - Studies have shown that close relatives of people with RA are at increased risk for developing the condition.

  • Rheumatoid factor - People who test positive for an autoantibody called rheumatoid factor (RF), which can be detected by a blood test, are at increased risk for developing RA. In fact, RF is used as a marker for diagnosing RA as well as for predicting the progression and outcome of the disease (prognostic marker).

  • Smoking - People who smoke cigarettes are about 2-4 times more likely to develop RA than nonsmokers.

  • Coffee - The relationship between coffee consumption and RA is unclear. While some studies suggest that coffee consumption increases the risk of RA other studies refute this claim.