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Clinical Trials

1. Ocular involvement in children with localised scleroderma: a multi-centre study.

Author: Zannin ME; Martini G; Athreya BH; Russo R; Higgins GC; Vittadello F; Alpigiani MG; Alessio M; Paradisi M; Woo P; Zulian F; Zannin ME; Martini G; Athreya BH; Russo R; Higgins G; Vittadello F; Alpigiani MG; Alessio M; Paradisi M; Woo P; Zulian F;
Institution: Department of Pediatrics, Via Giustiniani 3, 35128 Padova, Italy. ezannin@pediatria.unipd.it
Journal: Br J Ophthalmol. 2007 Oct;91(10):1311-4. Epub 2007 May 2.
Abstract URL: Click here to view abstract

2. The Pediatric Rheumatology European Society/American College of Rheumatology/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis.

Author: Zulian F; Woo P; Athreya BH; Laxer RM; Medsger TA Jr; Lehman TJ; Cerinic MM; Martini G; Ravelli A; Russo R; Cuttica R; de Oliveira SK; Denton CP; Cozzi F; Foeldvari I; Ruperto N;
Institution: Dipartimento di Pediatria, University of Padua, Padua, Italy. zulian@pediatria.unipd.it
Journal: Arthritis Rheum. 2007 Mar 15;57(2):203-12.
Abstract URL: Click here to view abstract

3. Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192.

Author: Denton CP; Merkel PA; Furst DE; Khanna D; Emery P; Hsu VM; Silliman N; Streisand J; Powell J; Akesson A; Coppock J; Hoogen F; Herrick A; Mayes MD; Veale D; Haas J; Ledbetter S; Korn JH; Black CM; Seibold JR;
Institution: Royal Free Hospital, London, UK. c.denton@medsch.ucl.ac.uk
Journal: Arthritis Rheum. 2007 Jan;56(1):323-33.
Abstract URL: Click here to view abstract

4. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study.

Author: Nash RA; McSweeney PA; Crofford LJ; Abidi M; Chen CS; Godwin JD; Gooley TA; Holmberg L; Henstorf G; LeMaistre CF; Mayes MD; McDonagh KT; McLaughlin B; Molitor JA; Nelson JL; Shulman H; Storb R; Viganego F; Wener MH; Seibold JR; Sullivan KM; Furst DE;
Institution: Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. rnash@fhcrc.org
Journal: Blood. 2007 Aug 15;110(4):1388-96. Epub 2007 Apr 23.
Abstract URL: Click here to view abstract

5. Home parenteral nutrition--an effective and safe long-term therapy for systemic sclerosis-related intestinal failure.

Author: Brown M; Teubner A; Shaffer J; Herrick AL;
Institution: University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, Manchester, UK.
Journal: Rheumatology (Oxford). 2008 Feb;47(2):176-9. Epub 2007 Dec 14.
Abstract URL: Click here to view abstract

6. Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients.

Author: Teixeira L; Mouthon L; Mahr A; Berezne A; Agard C; Mehrenberger M; Noel LH; Trolliet P; Frances C; Cabane J; Guillevin L;
Institution: Internal Medicine Department and Reference Center for Vasculitis and Systemic Sclerosis, Cochin Hospital, Assistance Publique-Hopitaux de Paris, and UPRES EA 4058, Paris-Descartes University, Faculty of Medicine, France.
Journal: Ann Rheum Dis. 2008 Jan;67(1):110-6. Epub 2007 Jun 8.
Abstract URL: Click here to view abstract

7. Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis.

Author: Vonk MC; Marjanovic Z; van den Hoogen FH; Zohar S; Schattenberg AV; Fibbe WE; Larghero J; Gluckman E; Preijers FW; van Dijk AP; Bax JJ; Roblot P; van Riel PL; van Laar JM; Farge D;
Institution: Department of Rheumatology, Radboud University Nijmegen Medical Centre, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. M.Vonk@reuma.umcn.nl
Journal: Ann Rheum Dis. 2008 Jan;67(1):98-104. Epub 2007 May 25.
Abstract URL: Click here to view abstract

8. Systemic sclerosis in childhood: clinical and immunologic features of 153 patients in an international database.

Author: Martini G; Foeldvari I; Russo R; Cuttica R; Eberhard A; Ravelli A; Lehman TJ; de Oliveira SK; Susic G; Lyskina G; Nemcova D; Sundel R; Falcini F; Girschick H; Lotito AP; Buoncompagni A; Sztajnbok F; Al-Mayouf SM; Orban I; Ferri C; Athreya BH; Woo P; Zulian F;
Institution: University of Padua, Padua, Italy.
Journal: Arthritis Rheum. 2006 Dec;54(12):3971-8.
Abstract URL: Click here to view abstract

9. A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma.

Author: Hoyles RK; Ellis RW; Wellsbury J; Lees B; Newlands P; Goh NS; Roberts C; Desai S; Herrick AL; McHugh NJ; Foley NM; Pearson SB; Emery P; Veale DJ; Denton CP; Wells AU; Black CM; du Bois RM;
Institution: Royal Brompton Hospital, Imperial College, London, UK.
Journal: Arthritis Rheum. 2006 Dec;54(12):3962-70.
Abstract URL: Click here to view abstract

10. Cyclophosphamide versus placebo in scleroderma lung disease.

Author: Tashkin DP; Elashoff R; Clements PJ; Goldin J; Roth MD; Furst DE; Arriola E; Silver R; Strange C; Bolster M; Seibold JR; Riley DJ; Hsu VM; Varga J; Schraufnagel DE; Theodore A; Simms R; Wise R; Wigley F; White B; Steen V; Read C; Mayes M; Parsley E; Mubarak K; Connolly MK; Golden J; Olman M; Fessler B; Rothfield N; Metersky M; Tashkin DP; Elashoff R; Clements PJ; Goldin J; Roth MD; Furst DE; Arriola E; Silver R; Strange C; Bolster M; Seibold JR; Riley DJ; Hsu VM; Varga J; Schraufnagel DE; Theodore A; Simms R; Wise R; Wigley F; White B; Steen V; Read C; Mayes M; Parsley E; Mubarak K; Connolly MK; Golden J; Olman M; Fessler B; Rothfield N; Metersky M; Tashkin DP; Elashoff R; Clements PJ; Goldin J; Roth MD; Furst DE; Arriola E; Silver R; Strange C; Bolster M; Seibold JR; Riley DJ; Hsu VM; Varga J; Schraufnagel DE; Theodore A; Simms R; Wise R; Wigley F; White B; Steen V; Read C; Mayes M; Parsley E; Mubarak K; Connolly MK; Golden J; Olman M; Fessler B; Rothfield N; Metersky M;
Institution: University of California at Los Angeles, Los Angeles, USA. dtashkin@mednet.ucla.edu
Journal: N Engl J Med. 2006 Jun 22;354(25):2655-66.
Abstract URL: Click here to view abstract

11. Systemic sclerosis-associated Sjogren's syndrome and relationship to the limited cutaneous subtype: results of a prospective study of sicca syndrome in 133 consecutive patients.

Author: Avouac J; Sordet C; Depinay C; Ardizonne M; Vacher-Lavenu MC; Sibilia J; Kahan A; Allanore Y; Avouac J; Sordet C; Depinay C; Ardizonne M; Vacher-Lavenu MC; Sibilia J; Kahan A; Allanore Y; Avouac J; Sordet C; Depinay C; Ardizonne M; Vacher-Lavenu MC; Sibilia J; Kahan A; Allanore Y; Avouac J; Sordet C; Depinay C; Ardizonne M; Vacher-Lavenu MC; Sibilia J; Kahan A; Allanore Y;
Institution: Rene Descartes University, Medical Faculty, Hopital Cochin, France.
Journal: Arthritis Rheum. 2006 Jul;54(7):2243-9.
Abstract URL: Click here to view abstract

12. Iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis and the quality of life: a new therapeutic protocol.

Author: Milio G; Corrado E; Genova C; Amato C; Raimondi F; Almasio PL; Novo S;
Institution: Department of Internal Medicine and Cardiovascular Diseases, University of Palermo, Palermo, Italy. glaucomilio@libero.it
Journal: Rheumatology (Oxford). 2006 Aug;45(8):999-1004. Epub 2006 Feb 16.
Abstract URL: Click here to view abstract

13. Low-dose intravenous cyclophosphamide in systemic sclerosis: an open prospective efficacy study in patients with early diffuse disease.

Author: Valentini G; Paone C; La Montagna G; Chiarolanza I; Menegozzo M; Colutta E; Ruocco L; Valentini G; Paone C; La Montagna G; Chiarolanza I; Menegozzo M; Colutta E; Ruocco L;
Institution: The Rheumatology Health Unit, Second University of Naples, Italy. gabriele.valentini@unina2.it
Journal: Scand J Rheumatol. 2006 Jan-Feb;35(1):35-8.
Abstract URL: Click here to view abstract

14. A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma.

Author: Kreuter A; Hyun J; Stucker M; Sommer A; Altmeyer P; Gambichler T; Kreuter A; Hyun J; Stucker M; Sommer A; Altmeyer P; Gambichler T;
Institution: Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany. a.kreuter@derma.de
Journal: J Am Acad Dermatol. 2006 Mar;54(3):440-7. Epub 2006 Jan 30.
Abstract URL: Click here to view abstract

15. Localized scleroderma in childhood is not just a skin disease.

Author: Zulian F; Vallongo C; Woo P; Russo R; Ruperto N; Harper J; Espada G; Corona F; Mukamel M; Vesely R; Musiej-Nowakowska E; Chaitow J; Ros J; Apaz MT; Gerloni V; Mazur-Zielinska H; Nielsen S; Ullman S; Horneff G; Wouters C; Martini G; Cimaz R; Laxer R; Athreya BH;
Institution: Dipartimento di Pediatria, Universita di Padova, Padua, Italy. zulian@pediatria.unipd.it
Journal: Arthritis Rheum. 2005 Sep;52(9):2873-81.
Abstract URL: Click here to view abstract

16. A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis.

Author: Nadashkevich O; Davis P; Fritzler M; Kovalenko W;
Institution: Department of Internal Medicine/Rheumatology, L'viv Medical University, L'viv, Ukraine.
Journal: Clin Rheumatol. 2006 Mar;25(2):205-12. Epub 2005 Oct 14.
Abstract URL: Click here to view abstract

17. A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis.

Author: Knobler RM; French LE; Kim Y; Bisaccia E; Graninger W; Nahavandi H; Strobl FJ; Keystone E; Mehlmauer M; Rook AH; Braverman I; Knobler RM; French LE; Kim Y; Bisaccia E; Graninger W; Nahavandi H; Strobl FJ; Keystone E; Mehlmauer M; Rook AH; Braverman I; Knobler RM; French LE; Kim Y; Bisaccia E; Graninger W; Nahavandi H; Strobl FJ; Keystone E; Mehlmauer M; Rook AH; Braverman I; Knobler RM; French LE; Kim Y; Bisaccia E; Graninger W; Nahavandi H; Strobl FJ; Keystone E; Mehlmauer M; Rook AH; Braverman I;
Institution: Department of Dermatology, Medical University of Vienna, Vienna, Austria. robert.knobler@meduniwien.ac.at
Journal: J Am Acad Dermatol. 2006 May;54(5):793-9.
Abstract URL: Click here to view abstract

18. Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma.

Author: Kreuter, Alexander; Gambichler, Thilo; Breuckmann, Frank; Rotterdam, Sebastian; Freitag, Marcus; Stuecker, Markus; Hoffmann, Klaus; Altmeyer, Peter;
Institution: Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany. a.kreuter@derma.de
Journal: Arch Dermatol 2005 Jul;141(7):847-52.
Abstract URL: Click here to view abstract

19. Computerized nailfold video capillaroscopy--a new tool for assessment of Raynaud's phenomenon.

Author: Anderson, Marina E; Allen, P Danny; Moore, Tonia; Hillier, Val; Taylor, Christopher J; Herrick, Ariane L;
Institution: University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK.
Journal: J Rheumatol 2005 May;32(5):841-8.
Abstract URL: Click here to view abstract

20. Prevention of amputation caused by rheumatic diseases following a novel therapy of exposing bone marrow, occlusive dressing and subsequent epidermal grafting.

Author: Yamaguchi, Y; Sumikawa, Y; Yoshida, S; Kubo, T; Yoshikawa, K; Itami, S;
Institution: Department of Dermatology, Graduate School of Medicine Osaka University, 2-2 Yamada-oka, Suita-shi, Osaka 565-0871, Japan.
Journal: Br J Dermatol 2005 Apr;152(4):664-72.
Abstract URL: Click here to view abstract

21. New hope for systemic sclerosis patients with digital ulcers.

Author: Varga, John;
Institution
Journal: Curr Rheumatol Rep 2005 Apr;7(2):127-8.

22. Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung Study.

Author: Khanna, Dinesh; Clements, Philip J; Furst, Daniel E; Chon, Yun; Elashoff, Robert; Roth, Michael D; Sterz, Mildred G; Chung, Joannie; FitzGerald, John D; Seibold, James R; Varga, John; Theodore, Arthur; Wigley, Fredrick M; Silver, Richard M; Steen, Virginia D; Mayes, Maureen D; Connolly, M Kari; Fessler, Barri J; Rothfield, Naomi F; Mubarak, Kamal;
Institution: David Geffen School of Medicine, University of California, Los Angeles,USA. dinesh.khanna@uc.edu <dinesh.khanna@uc.edu>
Journal: Arthritis Rheum 2005 Feb;52(2):592-600.
Abstract URL: Click here to view abstract